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Updated: May 10, 2025

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化物含量,可用性和稳定性在基牙膏中
Mara Assef Leitão Lotif1, Lidia Audrey Rocha Valadas1,2, Peter Bottenberg3
1Pharmacy Department, Pharmacy, Dentistry and Nursing College, Federal University of Ceara, 1210 Pastor Samuel Mulunga Street 60430372, Fortaleza, Ceara, Brazil.
International journal of dentistry
|April 21, 2025
概括
巴西红色石牙膏显示稳定可溶性化物12个月. 然而,在老化24个月后,化物度显著下降.
科学领域:
- 口腔健康 口腔健康
- 材料科学 材料科学 材料科学
背景情况:
- 化物牙膏对于预防牙至关重要.
- 巴西红色 (BRP) 具有潜在的治疗特性.
- 调查含有BRP的牙膏中化物的稳定性对于产品的有效性至关重要.
研究的目的:
- 为了评估总化物 (TF),总溶性化物 (TSF) 和电离性化物 (IF) 在用巴西红色 (BRP) 配制的牙膏中的稳定性.
- 在24个月的时间内确定老化对BRP牙膏化物含量的影响.
主要方法:
- 制造了一种含有碳酸和单酸 (MFP) 的牙膏,含有1500μg/g化物.
- 使用离子特异电极 (ISE) 测量化物度 (TF,TSF,IF) 在0,12和24个月.
- 对来自多个批次的五批进行了重复分析.
主要成果:
- 12个月后,TF的范围从1198.9到1443.6 ppm F,TSF从869.6到965.8 ppm F,IF从223.5到269.7 ppm F.
- 24个月后,TF在763.5到1083.1ppmF,TSF在552.3到758.4ppmF,IF在102.2到174.7ppmF之间.
- 可溶性化物 (TSF和IF) 显示了长达12个月的相对稳定性,但在24个月内显著下降.
结论:
- 在最初的12个月里,BRP牙膏表现出可接受的化物稳定性.
- 在24个月的时间点观察到可溶性化物度的显著降低.
- 可能需要进一步的研究,以优化含有BRP的牙膏中长期化物稳定性的配方.
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