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治疗前的血液参数作为经济预测标志物,用于预测局部晚期宫癌治疗反应

Abhishek Krishna¹, Vishnumaya N¹, Fathima Shada¹

¹Department of Radiation Oncology, Kasturba Medical College Mangalore, Manipal Academy of Higher Education, Karnataka, Manipal, India.

|April 21, 2025

概括

治疗前的血标记物如血红蛋白和中性粒细胞与淋巴细胞比率 (NLR) 可以预测宫癌治疗反应. 较低的血红蛋白和较高的NLR表明结果较差,有助于个性化治疗决策.

科学领域:

在瘤学瘤学.
血液学血液学血液学
生物标志物研究生物标志物研究

背景情况:

子宫癌是全球主要的健康问题,特别是在低收入国家.
基于西斯普拉丁的化学辐射是局部晚期子宫癌的标准.
血液学参数正在成为预后生物标志物.

研究的目的:

评估治疗前的血液学参数,作为局部晚期宫癌治疗反应的预测指标.
通过ROC分析确定关键生物标志物的最佳切断值.

主要方法:

在2021年1月至2022年6月期间治疗的140名患者的回顾性分析.
评估的血红蛋白,中性粒细胞与淋巴细胞的比率 (NLR),血小板与淋巴细胞的比率 (PLR),预后营养指数 (PNI) 和乙氨基蛋白比率 (EAR).
使用的接收器运行特征 (ROC) 曲线分析以确定生物标志物的截止值.

主要成果:

86.4%的患者实现了完全的反应.
与响应者相比,非响应者血红蛋白,NLR和EAR较高,PNI较低.
识别了用于预测反应的ROC衍生的切断值:血红蛋白 (<9.5),NLR (<2.98),PLR (>289.26),PNI (<37.67),EAR (<49.63).

结论:

治疗前的血液参数可以预测宫癌的治疗反应.
特定的生物标志物水平 (例如,低血红蛋白,高NLR) 与较差的结果有关.
这些生物标志物可能有助于个性化治疗策略,需要进一步验证.

关键词:

关键词: 宫癌宫癌宫癌化学辐射的发生.在治疗前的血液参数.预后标志物预后标志物治疗反应.治疗反应.

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