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Updated: May 10, 2025

Continuous Fluorescence-Based Endonuclease-Coupled DNA Methylation Assay to Screen for DNA Methyltransferase Inhibitors
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Continuous Fluorescence-Based Endonuclease-Coupled DNA Methylation Assay to Screen for DNA Methyltransferase Inhibitors

Published on: August 5, 2022

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选择性抑制剂设计针对Mycobacterium结核病的提米酸合成酶使用炼化模拟

Pallav Sengupta1, Priyadarshi Satpati1

  • 1Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, Assam 781039, India.

ACS omega
|April 21, 2025
PubMed
概括

研究人员设计了新的类似药物的配体,可以选择性地抑制Mycobacterium tuberculosis (MtbThyX) 中的甲基胺酸合成酶. 连接物L2对MtbThyX具有很高的亲和力,对人体胆酸合成酶 (hThyA) 具有很低的亲和力,为新的结核病治疗提供了有希望的策略.

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