MTHFR,MTRR基因多态和H型高血压之间的关系:系统性审查和元分析
Lan Gao1, Lisen Dong2, Yixuan Niu2
1School of Pharmacy, Inner Mongolia Medical University, Hohhot, Inner Mongolia, China.
Annals of human biology
|April 21, 2025
概括
甲基基酸减少酶 (MTHFR) C677T基因变异与健康和非H型高血压个体的H型高血压易感性有关. 这一元分析澄清了关于MTHFR和MTRR基因多态和高血压风险的不一致发现.
科学领域:
- 遗传学 遗传学 是一个
- 心血管疾病流行病学
- 分子生物学分子生物学
背景情况:
- 存在不一致的发现,关于甲基酸酸减少酶 (MTHFR) 和甲氨酸合成减少酶 (MTRR) 基因多态和H型高血压易感性之间的关联.
- 澄清这些遗传关联对于了解高血压风险因素至关重要.
研究的目的:
- 进行元分析,精确评估MTHFR (C677T/A1298C) 和MTRR (A66G) 基因多态性与H型高血压敏感性之间的关系.
主要方法:
- 在六个英语和四个中文数据库中进行了全面的文献搜索,截至2023年8月.
- 包括的研究评估了与H型高血压相关的MTHFR C677T/A1298C和MTRR A66G多态.
- 对24项研究的数据进行了元分析,其中包括3649名H型高血压患者,2772名非H型高血压患者和2149名健康对照患者.
主要成果:
- 在健康个体和非H型高血压患者中,MTHFR C677T多态性与H型高血压有显著的关联 (TT与CC:OR=3.43,95%CI=2.48-4.75).
- 亚组分析表明,中国南部人口的同类半氨酸水平更容易受到MTHFR C677T多态 (p < 0.05) 的影响.
- 在所有遗传模型中,没有发现MTHFR A1298C和MTRR A66G多态的显著关联.
结论:
- 在非H型高血压患者和健康个体中,MTHFR C677T多态显著与H型高血压有关.
- MTHFR A1298C和MTRR A66G的多态性似乎与H型高血压风险无关.
- 地理因素,特别是在中国南部,可能会影响与MTHFR C677T变异相关的H型高血压的易感性.
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