经典迷幻药的创伤期消费与暴露3周后的较低焦虑和创伤后反应有关
Einat Karp Barnir1, Zohar Rubinstein1, Rany Abend1
1School of Psychology, Reichman University, Herzliya, Israel.
Journal of psychopharmacology (Oxford, England)
|April 21, 2025
概括
经典的迷幻药可能会防止创伤. 在恐怖袭击期间使用经典迷幻药物的幸存者报告说,焦虑和创伤后压力比其他人少.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 创伤后应激障碍 (PTSD) 是一种使人虚弱的疾病,治疗选择有限.
- 迷幻化合物显示PTSD的治疗潜力,但它们的机制尚未完全理解.
- 了解迷幻药如何影响创伤性记忆的形成,对于开发有针对性的疗法至关重要.
研究的目的:
- 调查经典迷幻药物对大规模创伤事件后焦虑和创伤后压力症状的潜在保护作用.
- 探索经典迷幻药在调节创伤记忆形成中的作用.
主要方法:
- 在恐怖袭击事件发生三周后,对343名成年幸存者的焦虑和创伤后症状进行了评估.
- 参与者报告说他们在袭击期间使用了各种迷幻化合物,包括经典的迷幻药物和3,4-甲基二氧化甲胺 (MDMA).
- 基于物质使用的群体之间的症状水平进行了比较,并对共用娱乐性药物的影响进行了额外的分析.
主要成果:
- 在袭击期间食用经典迷幻药的人报告了与使用MDMA或不使用迷幻药的人相比,焦虑和创伤后反应水平明显较低.
- 经典迷幻药的保护作用在没有使用额外的娱乐性物质的参与者中更为明显.
- 这些发现表明,经典迷幻药对创伤记忆背后的神经生物学过程具有潜在的调节作用.
结论:
- 经典的迷幻药可能通过调节持久创伤记忆的形成,对PTSD和焦虑的发展产生保护作用.
- 经典迷幻药的药理目标可能代表了预防或治疗创伤相关疾病的新疗法.
- 需要进一步的研究来阐明经典迷幻药能发挥这些保护作用的确切机制.
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