从海洋来源的细菌 velezensis 对抗疹病毒的Epimeric Macrolactin类似物
Shuaiqi Ma1, Shuting Zou2, Asma Riaz1
1Group of Peptides and Natural Products Research, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.
Chemistry & biodiversity
|April 21, 2025
概括
来自Bacillus velezensis的两种新型糖基化宏酸体对疹病毒表现出强烈的抗病毒活性. 这些化合物从红树林细菌中分离出来,提供了有前途的治疗潜力,几乎与阿西克洛维尔相匹配.
科学领域:
- 自然产品化学 自然产品化学
- 微生物学 微生物学
- 病毒学 病毒学
背景情况:
- 红树林生态系统中的内生菌是新型生物活性化合物的丰富来源.
- 众所周知,Bacillus velezensis产生各种二次代谢产物,具有潜在的制药应用.
研究的目的:
- 从Bacillus velezensis中分离和表征新的糖基化宏类.
- 评估隔离化合物对疹病毒的抗病毒活性.
主要方法:
- 使用色谱技术分离和净化化合物.
- 使用1D和2D核磁共振 (NMR) 谱学和高分辨率电喷射电离化质谱学 (HR-ESI-MS) 阐明结构.
- 使用定量实时聚合酶链反应 (qRT-PCR) 和西布洛特测试进行抗病毒活性评估.
主要成果:
- 两种新的糖基化宏化物,指定化合物1和2,与五种已知的化合物一起被确定.
- 化合物1和2对疹病毒具有显著的抗病毒疗效,在5μg/mL时达到约85%的抑制.
- 观察到的抗病毒活性与阳性对照药,阿西克洛维尔,相似.
结论:
- 固体细胞细菌Bacillus velezensis含有具有强大的抗病毒功能的新型糖基化宏化物.
- 化合物1和2代表了开发新的抗疹病毒治疗药物的有希望的候选者.
- 对作用机制和结构-活动关系的进一步研究是有必要的.
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