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在COVID-19中持续的嗅觉功能障碍的患病率和恢复率:COVORTS研究
B van Dijk1, E M Postma1,2, W M Boek2
1Division of Human Nutrition and Health, Wageningen University and Research, Wageningen, the Netherlands.
在COVID-19后持续的嗅觉功能障碍持续高达15个月,恢复率低. 个体症状的波动凸显了持续的患者监测和管理策略的必要性.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 传染性疾病 传染性疾病
- 神经学 神经学
背景情况:
- 嗅觉功能障碍是COVID-19的一个常见症状.
- 在现有文献中,COVID后嗅觉功能障碍的患病率和康复率存在显著差异.
- 这项研究调查了COVID-19感染后的长期嗅觉功能障碍.
研究的目的:
- 确定定量嗅觉功能障碍的流行率和恢复率.
- 评估质量上的嗅觉问题,包括帕洛斯米亚和斯米亚.
- 在感染后15个月内评估主观的嗅觉功能.
主要方法:
- 科沃茨队列包括76名患者 (18-60岁) 最近有嗅觉功能障碍.
- 量化嗅觉测试 (嗅探棒) 在基线和12个月后进行.
- 每月在线调查问卷追踪主观嗅觉功能和定性投诉.
主要成果:
- 在基线时,定量嗅觉功能障碍影响了89.5%,在12个月后降至69.1%.
- 帕洛斯米亚仍然很普遍 (约为50%),而斯米亚从43.4%降至23.5%.
- 主体嗅觉功能改善到大约50%的疾病前的能力,并注意到波动.
结论:
- 嗅觉功能障碍仍然普遍存在,COVID-19后15个月的恢复速度很慢.
- 观察到的个体波动表明恢复模式不稳定.
- 改善患者管理需要承认症状,理解波动,并延长后续.
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