在原发性渐进性多发性硬化症中,自和髓的致病性参与
Simone Patergnani1, Michele Laudisi2, Massimo Bonora1
1Department of Medical Sciences, Section of Experimental Medicine, and Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, Ferrara, Italy.
Journal of cellular and molecular medicine
|April 21, 2025
概括
细胞循环的关键过程,即自和线,在初级渐进性多发性硬化症 (PPMS) 患者中显著减少. 这些发现表明了早期检测和监测PPMS的潜在生物标志物.
科学领域:
- 神经科学是一个神经科学.
- 细胞生物学 细胞生物学
- 生物化学 生物化学
背景情况:
- 初级渐进性多发性硬化症 (PPMS) 是一种衰弱的神经系统疾病,分子机制不明,治疗选择有限.
- 目前对PPMS的诊断和监测工具缺乏特异性,阻碍了早期干预和疾病管理.
- 自和髓是维持细胞健康和功能所涉及的重要细胞过程,特别是在神经元中.
研究的目的:
- 调查自和髓在PPMS的发病过程中的作用.
- 确定潜在的循环生物标志物,以便早期检测和监测PPMS.
- 探索PPMS中自,髓和神经退行症之间的关系.
主要方法:
- 从PPMS患者,复发性复发性硬化症 (RRMS) 患者和健康对照组收集血清样本.
- 使用生物化学分析量化了自标志物 (ATG5,ATG7) 和线标志物 (Parkin,Optineurin) 的水平.
- 还评估了神经退行和线粒体功能障碍的标记物.
- 进行了相关性分析,以调查自,髓和疾病标志物之间的关系.
主要成果:
- 与对照和RRMS患者相比,PPMS患者的血清中自标志物 (ATG5,ATG7) 和线标志物 (Parkin,Optineurin) 在血清中显著降低.
- 减少的自和髓与PPMS患者的神经退行和线粒体功能障碍的标志物增加有关.
- 在PPMS组中观察到自和髓蛋白之间的正相关性,表明它们的相互关联调节.
- 在不同多发性硬化症亚型中发现了明显的自和髓模式.
结论:
- 自和髓在PPMS的病理生理学中起着重要作用.
- 循环水平的自和髓标志物在PPMS中显示出不同的模式,表明它们作为早期诊断生物标志物的潜力.
- 对调节自和髓的进一步研究可能为PPMS提供新的治疗策略.
相关概念视频
01:27Autophagy
4.0K
Autophagy is a self-digesting process by which a cell protects itself from threats both within and outside the cell, ranging from abnormal proteins to invading bacteria. In this process, obsolete components of the cell and invading microbes are degraded by hydrolytic enzymes active in an acidic environment of the lysosomal lumen.
An autophagic pathway consists of a series of signaling events activated in response to diverse stress and physiological conditions such as food deprivation,...
An autophagic pathway consists of a series of signaling events activated in response to diverse stress and physiological conditions such as food deprivation,...
4.0K
01:36Delivery Pathways to the Lysosome
6.1K
Eukaryotic cells use different mechanisms to eliminate toxic waste obsolete and worn-out substances. Lysosomes play a pivotal role in this, and hence, these substances are carried to the lysosome from other parts of the cell and extracellular space through different pathways. The most elaborately studied pathways to the lysosome are the endocytic pathways.
Endocytosis
In endocytosis, the cell membrane takes up macromolecules and particles from the surrounding medium. Clathrin-mediated...
Endocytosis
In endocytosis, the cell membrane takes up macromolecules and particles from the surrounding medium. Clathrin-mediated...
6.1K
01:18Autophagic Cell Death
2.7K
Christian de Duve discovered “autophagy,” a process in which cellular components are engulfed by membrane-bound organelles called autophagosomes. The autophagosomes then fuse with lysosomes to digest the enclosed contents. Autophagy is generally activated in cells to prevent cell death. However, cell death is triggered when the damage is beyond repair.
Autophagy and Apoptosis
Autophagy can activate apoptosis. In normal conditions, the autophagy activating protein Beclin-1 and...
Autophagy and Apoptosis
Autophagy can activate apoptosis. In normal conditions, the autophagy activating protein Beclin-1 and...
2.7K
01:22Lysosomal Hydrolases
3.7K
Lysosomes are the site for the degradation of macromolecules and biological polymers released during membrane trafficking events such as secretory, endocytic, autophagic, and phagocytic pathways. The membrane-enclosed area of the lysosome, called the lumen, contains hydrolytic enzymes active in an acidic environment. These acid hydrolases are functional at a pH between 4.5 and 5 and are involved in cellular processes such as cell signaling, energy metabolism, restoration of the plasma membrane,...
3.7K