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相关概念视频

Diversity of Antigen Receptors01:28

Diversity of Antigen Receptors

374
Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
374
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

531
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
531
Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

332
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
332
Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

725
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
725
Antigen Presenting Cells01:22

Antigen Presenting Cells

1.3K
The immune system is a complex network of cells and molecules that protects the body from foreign invaders. T cells, a type of white blood cell, play a crucial role in this process. They recognize and attack foreign substances, such as pathogens, that enter the body.
T cells require the help of antigen-presenting cells (APCs), which process foreign antigens into smaller fragments that can be recognized by T cells. These APCs are highly specialized cells that efficiently internalize antigens...
1.3K
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

625
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
625

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相关实验视频

Updated: May 10, 2025

Using X-ray Crystallography, Biophysics, and Functional Assays to Determine the Mechanisms Governing T-cell Receptor Recognition of Cancer Antigens
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Using X-ray Crystallography, Biophysics, and Functional Assays to Determine the Mechanisms Governing T-cell Receptor Recognition of Cancer Antigens

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TRAIT:T细胞受体-抗原相互作用的综合数据库

Mengmeng Wei1,2, Jingcheng Wu1, Shengzuo Bai1

  • 1National Key Laboratory of Advanced Drug Delivery and Release Systems & Zhejiang Provincial Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.

Genomics, proteomics & bioinformatics
|April 21, 2025
PubMed
概括

一个新的数据库,TRAIT,提供了全面的T细胞受体 (TCR) -抗原相互作用数据. 这个资源整合了序列,结构和亲和关系,以推进T细胞免疫疗法和疫苗设计.

关键词:
抗原识别对抗原的识别突变 突变 突变 突变一个单细胞的奥米克.T细胞受体抗原相互作用基于T细胞的免疫疗法

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T and B Cell Receptor Immune Repertoire Analysis using Next-generation Sequencing
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T and B Cell Receptor Immune Repertoire Analysis using Next-generation Sequencing

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Generating De Novo Antigen-specific Human T Cell Receptors by Retroviral Transduction of Centric Hemichain
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相关实验视频

Last Updated: May 10, 2025

Using X-ray Crystallography, Biophysics, and Functional Assays to Determine the Mechanisms Governing T-cell Receptor Recognition of Cancer Antigens
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Using X-ray Crystallography, Biophysics, and Functional Assays to Determine the Mechanisms Governing T-cell Receptor Recognition of Cancer Antigens

Published on: February 6, 2017

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T and B Cell Receptor Immune Repertoire Analysis using Next-generation Sequencing
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Generating De Novo Antigen-specific Human T Cell Receptors by Retroviral Transduction of Centric Hemichain
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Generating De Novo Antigen-specific Human T Cell Receptors by Retroviral Transduction of Centric Hemichain

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科学领域:

  • 免疫学 免疫学 免疫学
  • 生物信息学是一种生物信息学.
  • 计算生物学 计算生物学

背景情况:

  • 目前对T细胞受体 (TCR) -抗原相互作用的现有资源不足以推进采用T细胞免疫疗法.
  • 了解TCR抗原识别机制对于开发有效的免疫疗法至关重要.

研究的目的:

  • 引入T细胞受体-抗原相互作用数据库 (TRAIT),这是一个新的,对TCR-抗原相互作用的综合资源.
  • 为研究TCR抗原识别提供一个全面的平台,有助于T细胞免疫疗法和疫苗开发.

主要方法:

  • 从实验数据中集成的TCR序列,结构和亲缘关系.
  • 利用单细胞欧米克数据作为TCR抗原相互作用的主要来源.
  • 包括来自临床试验的TCR抗原突变和TCR的数据.

主要成果:

  • 开发了TRAIT,一个数据库,概述了数百万经实验验证的TCR-抗原对.
  • TRAIT提供了抗原特异性TCR的详尽地图,包括非交互式TCR.
  • 该数据库详细介绍了TCR-抗原相互作用,包括突变的影响,支持亲和力成熟和疫苗设计.

结论:

  • TRAIT为TCR抗原相互作用提供了一个独特而全面的资源,这对于基于T细胞的免疫疗法至关重要.
  • 该数据库预计将通过阐明复杂的TCR抗原识别来推动算法和治疗的进步.
  • TRAIT是免费访问的,促进免疫学和免疫治疗领域的研究和开发.