长期暴露于颗粒物物质可能会增加慢性鼻炎与鼻多重症的风险:与暴露相匹配的研究结果
Rory J Lubner1, Mason Krysinski1, Ping Li1
1Department of Otolaryngology-Head and Neck Surgery, University of Alabama at Birmingham, Birmingham, AL.
International forum of allergy & rhinology
|April 21, 2025
概括
暴露于颗粒物 (PM$_{2.5}$) 可能会增加患有鼻多重症慢性鼻炎 (CRSwNP) 的风险. 较高的PM$_{2.5}$水平与对照人群中IL-10的减少有关,这表明它在疾病发病过程中发挥了作用.
科学领域:
- 环境健康 环境健康
- 免疫学 免疫学 免疫学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
背景情况:
- 颗粒物 (PM$_{2.5}$) 涉及慢性鼻炎 (CRS) 的致病性.
- 以前的研究表明,PM$_{2.5}$可能会在CRS中促进2型炎症.
- 关于与PM$_{2.5}$暴露相关的CRS鼻腔组织中细胞因子变化的数据有限.
研究的目的:
- 调查长期PM$_{2.5}$暴露与CRS发展之间的关联.
- 为了比较CRS患者的细胞因子概况与对照对PM$_{2.5}$暴露的控制.
- 为了确定PM$_{2.5}$暴露是否会增加CRS与鼻多重症 (CRSwNP) 的风险.
主要方法:
- 对376名患者的回顾性分析 (308名CRS,68名对照).
- 时空机器学习估计了手术前一年的每日PM$_{2.5}$水平.
- 细胞因子通过多重试验量化;使用回归模型分析与PM$_{2.5}$的相关性.
主要成果:
- 在对照患者中,降低IL-10水平与更高的PM相相关.
- 在调整后,独立预测的高12个月PM$_{2.5}$风险CRSwNP (OR:7.22,p=0.0001).
- 没有发现CRS无鼻多重症 (CRSsNP) 的类似关联.
结论:
- 与CRS患者相比,PM$_{2.5}$暴露与对照中的IL-10降低有关.
- 长期的PM$_{2.5}$暴露可能会增加患CRSwNP的风险.
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