在儿童中药物诱导的失脂症
Minali Patel1, Alejandro de la Torre2
1Department of Pharmacy, Cook Children's Medical Center, Fort Worth, TX, USA. minali.patel@cookchildrens.org.
Current atherosclerosis reports
|April 21, 2025
概括
儿科血脂不良症正在上升,增加了动脉样硬化心血管疾病 (ASCVD) 的风险. 非降脂药物可以影响儿童.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 心血管医学 心血管医学
- 药理学 药理学是指药理学的学科.
背景情况:
- 儿童血脂障碍和心血管疾病 (CVD) 风险正在增加,超过20%的儿童的BMI>95百分位.
- 动脉样硬化的证据出现在童年,并进展到成年.
- 不健康的生活方式和某些药物导致儿童脂质和脂蛋白的升高.
研究的目的:
- 审查非降脂药物对18岁以下儿童脂质和脂蛋白代谢的影响.
- 通知临床医生关于可能对儿科患者的脂质水平产生不利影响的药物.
主要方法:
- 关于儿科脂质代谢和药物效应研究的文献综述.
- 分析国家卫生统计中心关于儿童肥胖和心血管疾病风险的数据.
- 确定已知影响成人和儿童脂质水平的药物类别.
主要成果:
- 大约有40.1%的17岁以下的儿童在过去一年中至少接受过一种药物处方.
- 药物包括皮质类固醇,视网类固醇,β抑制剂,口服避孕药,化疗,抗逆转录病毒药物和行为药物可以影响儿科脂质谱.
- 在评估儿科脂质疾病时,医疗保健提供者必须考虑药物的副作用.
结论:
- 非降脂药物是儿童缺脂症的重要次要原因.
- 对这些药物效应的认识对于准确诊断和治疗儿科脂质疾病至关重要.
- 需要进一步的研究来了解这些药物对儿科心血管健康的长期影响.
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