脑垂体腺瘤患者的冲动控制障碍与多巴胺激动剂或不使用多巴胺激动剂进行治疗:来自英国中心的横截面研究
Ross Hamblin1,2,3, Mary White2,3, Athanasios Fountas1,2,3
1Department of Metabolism and Systems Science, College of Medicine and Health, University of Birmingham, IBR Tower, Level 2, Birmingham, B15 2TT, UK.
Pituitary
|April 21, 2025
概括
在垂体腺瘤患者,特别是患有前列腺瘤的患者中,多巴胺激动剂治疗与冲动控制障碍 (ICD) 的更高患病率有关. 评估工具对观察到的结果有很大的影响.
科学领域:
- 神经内分泌学神经内分泌学
- 精神病学是一个精神病学.
- 临床药理学 临床药理学
背景情况:
- 垂体腺瘤是影响激素调节的常见瘤.
- 多巴胺激动剂 (DAs) 经常用于治疗与益生菌瘤相关的超益生菌血症.
- 有关DA治疗与冲动控制障碍 (ICD) 之间的关联存在担忧.
研究的目的:
- 为了调查英国患有下垂体腺瘤的患者中ICDs的患病率.
- 为了比较用多巴胺激动剂治疗的患者与未接受DA治疗的患者的ICD率.
- 评估不同评估工具对ICD检测的影响.
主要方法:
- 这是一项涉及200名患有前乳腺瘤,巨瘤或非功能性垂体腺瘤 (NFPA) 的成年患者的横截面研究.
- 患者使用明尼苏达州冲动障碍访谈 (MIDI) 和帕金森病评分尺度冲动-强迫障碍问卷 (QUIP-RS) 进行评估.
- 对照组包括接受DA治疗的患者和未接受DA治疗的患者.
主要成果:
- 在DA治疗的前乳腺瘤患者中,与非DA治疗的NFPA患者相比,观察到更高的ICD患病率 (MIDI:12.7%对1.4%;QUIP-RS:46.5%对18.6%).
- 在MIDI上,DA使用与所有ICD的阳性分数相关,在QUIP-RS上,强迫性购买/爱好.
- 与非DA治疗的患者相比,在接受DA治疗的巨患者中没有发现ICD得分的显著差异.
结论:
- 接受DA治疗的英格兰患有益生菌瘤的患者表现出较高的ICD患病率,而不是非DA的NFPA患者.
- 选择ICD评估工具会影响检测到的患病率和特定类型的疾病.
- 需要进一步的研究,以了解DA-ICD在垂体腺瘤管理中的关联.
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