药物治疗阿片类药物使用障碍和怀孕个人的治疗保留
Valerie S Ganetsky1, Noa Krawczyk2, Alene Kennedy-Hendricks1
1Department of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
JAMA network open
|April 21, 2025
概括
治疗阿片类药物使用障碍 (MOUD) 的药物显著改善了阿片类药物使用障碍 (OUD) 的孕妇的治疗保留率. 然而,整体保留率仍然很低,这凸显了在专业护理机构中继续整合MOUD的必要性.
科学领域:
- 成 药物 药物 药物 药物
- 公共卫生 公共卫生
- 孕产妇健康 孕产妇健康
背景情况:
- 对于患有阿片类药物使用障碍 (OUD) 的孕妇,保持治疗至关重要,特别是在高强度合成阿片类药物 (HPSO) 时代.
- 有限的数据存在于阿片类药物使用障碍 (MOUD) 药物对这种人群在特殊物质使用治疗中的保留的影响.
研究的目的:
- 调查MOUD在治疗中加入和6个月的治疗延续之间的关联.
- 在HPSO时代,专注于在公共资助的专科治疗设施中治疗OUD的孕妇.
主要方法:
- 使用治疗情节数据集-释放 (2015-2021) 的横截面研究.
- 包括有OUD的孕妇在门诊,非密集型门诊机构接受治疗.
- 使用治疗加权后勤回归的逆概率来分析MOUD对6个月保留时间的影响.
主要成果:
- 大约三分之二的治疗情节包括MOUD,从2015年至2021年使用量增加.
- 包括MOUD与6个月的治疗保留率显著增加相关 (aOR,1.86).
- 据估计,MOUD将6个月的保留时间的概率提高了14.2个百分点.
结论:
- 将MOUD纳入治疗与改善OUD孕妇的怀孕保持有关.
- 尽管有所改善,但在HPSO时代,整体治疗保留率仍然很低.
- 研究结果强调了MOUD在提高高风险群体OUD结果方面的重要性.
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