优化抗PD-1/PD-L1疗法疗效和便微生物种移植通过肠道菌群基于肠道类型的供体选择

Muni Hu1, Xiaoqiang Zhu2, Xiaowen Huang1

  • 1State Key Laboratory of Systems Medicine for Cancer, NHC Key Laboratory of Digestive Diseases, Division of Gastroenterology and Hepatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease, Shanghai Cancer Institute, Shanghai 200001, China.

Cell reports
|April 21, 2025
PubMed
概括

肠道菌群对癌症免疫治疗的成功有影响. 研究人员确定了有利和不利的肠道真菌肠类型,有利的类型预测了更好的反应,并通过便微生物群移植 (FMT) 实现了治疗增强.