结构阐明,抗氧化和神经保护特征的Physalis pubescens的L.多糖和它的改性产品
Yuxin Tan1, Lang Qiu1, Danqi Li2,3
1College of Chemical Engineering, Shenyang University of Chemical Technology, Shenyang, PR China.
Natural product research
|April 21, 2025
概括
果实多糖化物 (PPFP) 和其修饰衍生物 (Se-PPFP) 显示出显著的抗氧化和神经保护作用. Se-PPFP显示了增强的生物可用性和有效性,表明作为功能性食品成分的潜力.
科学领域:
- 食品科学 食品科学 食品科学
- 生物化学 生物化学
- 材料科学 材料科学 材料科学
背景情况:
- 菲萨利斯 pubescens L. 果实含有具有潜在生物活动的新型多糖体.
- 多糖因其多样化的功能性质而闻名,包括抗氧化作用.
- 开发新的功能性食品成分对于健康和健康至关重要.
研究的目的:
- 从Physalis pubescens L. fruits.中分离和鉴定一种新型多糖体 (PPFP).
- 合成一种修饰衍生物 (Se-PPFP) 具有增强的生物可用性.
- 评估PPFP和Se-PPFP的抗氧化和神经保护潜力.
主要方法:
- 使用分子量测定和糖结合分析等技术,对PPFP进行隔离和结构性表征.
- 使用HNO3-Na2SeO3方法合成Se-PPFP.
- 使用FT-IR和NMR光谱学对Se-PPFP的表征.
- 对抗氧化剂和神经保护作用的评估.
主要成果:
- 分离了一种新型的多糖体 (PPFP),其分子量为229.3kDa,主要由拉姆诺斯,阿拉比诺斯,福克斯,曼诺斯和葡萄糖组成.
- 成功地被纳入PPFP,形成Se-PPFP,具有增强的生物可用性,降低分子量,更松散的微观结构和更好的热稳定性.
- PPFP和Se-PPFP都表现出显著的抗氧化和神经保护作用,Se-PPFP表现出更明显的活性.
结论:
- PPFP及其衍生物Se-PPFP具有显著的抗氧化和神经保护性质.
- 与PPFP相比,Se-PPFP表现出更高的疗效,突出显示了修饰的好处.
- 这些发现表明PPFP和Se-PPFP作为健康应用的有价值的功能性食品成分的潜力.
更多相关视频
11:44Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B
Published on: January 19, 2022
2.4K
10:33Exploring the Two Herb Combination Strategy to Treat Injured PC12 Cells
Published on: November 18, 2022
1.2K
相关概念视频
01:20Radical Autoxidation
2.1K
The oxidation of an organic compound in the presence of air or oxygen is called autoxidation. For example, cumene reacts with oxygen to form hydroperoxide. Autoxidation involves initiation, propagation, and termination steps. Many organic compounds are susceptible to autoxidation—especially ethers in the presence of oxygen, which form hydroperoxides. Even though this reaction is slow, old ether bottles contain small amounts of peroxide, which leads to laboratory explosions during ether...
2.1K
01:17Oxidation of Phenols to Quinones
2.7K
In the presence of oxidizing agents, phenols are oxidized to quinones. Quinones can be easily reduced back to phenols using mild reducing agents. The electron-donating hydroxyl group enhances the reactivity of the aromatic ring, enabling oxidation of the ring even in the absence of an α hydrogen.
o-hydroxy phenols are oxidized to o-quinones and p-hydroxy phenols to p-quinones. Such redox reactions involve the transfer of two electrons and two protons. The reversible redox...
o-hydroxy phenols are oxidized to o-quinones and p-hydroxy phenols to p-quinones. Such redox reactions involve the transfer of two electrons and two protons. The reversible redox...
2.7K
01:30Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists
85
Cognitive enhancers, also known as "smart drugs," are substances used to enhance memory, mental alertness, and concentration. These can be natural or synthetic and improve cognition in conditions like Alzheimer's disease (AD) and other neurodegenerative diseases. Some common examples include caffeine, amphetamines, methylphenidate, modafinil, arecoline, donepezil, vortioxetine, and piracetam. These enhancers work on the principle of synaptic plasticity and altered circuit function.
85
01:29Drugs Affecting Neurotransmitter Synthesis
1.2K
Drugs affecting neurotransmitter synthesis can impact the adrenergic neuron and the synthesis of neurotransmitters. For example, α-methyltyrosine and carbidopa target specific enzymes involved in catecholamine synthesis. α-methyltyrosine inhibits the enzyme tyrosine hydroxylase, which converts tyrosine into dopamine. By blocking this enzyme, α-methyltyrosine reduces dopamine production and other catecholamines. Carbidopa, on the other hand, inhibits the enzyme dopa decarboxylase,...
1.2K
01:46Electron Transport Chain: Complex I and II
9.6K
The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...
ROS generation is regulated and maintained at moderate levels necessary...
9.6K