与HBeAg阴性慢性感染相比,HBeAg阴性不确定期肝细胞癌的风险增加
Vicki Wing-Ki Hui1,2,3, Grace Lai-Hung Wong1,2,3, Junlong Dai1,2,3
1Medical Data Analytics Centre.
Hepatology (Baltimore, Md.)
|April 21, 2025
概括
患有不确定的慢性乙型肝炎 (CHB) 和高HBVDNA的正常ALT的患者面临更高的肝细胞癌 (HCC) 风险. 抗病毒疗法在治疗和未治疗组之间的HCC风险没有显著差异.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 病毒学 病毒学
- 在瘤学瘤学.
背景情况:
- 不确定HBeAg阴性慢性乙型肝炎 (CHB) 的抗病毒疗法的益处尚未明确.
- 这一患者群的肝细胞癌 (HCC) 风险需要进一步调查.
研究的目的:
- 检查未确定阶段HBeAg阴性CHB.患者的HCC风险.
- 为了评估抗病毒治疗对HCC风险的影响,在这个特定的患者队列.
主要方法:
- 对以前未接受治疗的非肝硬化HBeAg阴性CHB患者的回顾性分析.
- 由氨酸氨基转移酶 (ALT) 水平和乙型肝炎病毒 (HBV) DNA 水平定义的不确定的阶段.
- 使用Cox比例危险模型来评估HCC风险和抗病毒疗法的效果.
主要成果:
- 在未确定阶段的患者与慢性感染患者相比,HCC风险明显更高 (aHR 1.587).
- 在不确定的阶段,高HBVDNA的正常ALT与高HBVDNA的异常ALT (aHR 1.377) 相比,高HBVDNA的正常ALT与更高的HCC风险相关.
- 在接受治疗和未接受治疗的患者之间没有观察到5年累计HCC发病率的显著差异.
结论:
- 患有不确定的CHB,正常ALT和高HBVDNA的患者表现出高HCC风险.
- 密切监测和及时的抗病毒治疗可能足以管理未经治疗的患者的HCC风险.
- 目前的数据表明,在未确定阶段的治疗和未治疗患者之间,HCC发病率没有显著差异.
更多相关视频
11:34A Competent Hepatocyte Model Examining Hepatitis B Virus Entry through Sodium Taurocholate Cotransporting Polypeptide as a Therapeutic Target
Published on: May 10, 2022
2.1K
07:32Author Spotlight: Investigating Immune Cell Dynamics in the Tumor Microenvironment — Challenges and Innovations in Cancer Prognosis
Published on: April 12, 2024
1.1K
相关概念视频
01:25Hepatitis
Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...
01:26Gastritis II: Pathophysiology
The pathophysiology of gastritis begins with the colonization of the stomach lining by Helicobacter pylori (H. pylori). This bacterium spreads mainly via the oral-oral route through saliva or shared utensils, and can also be transmitted in overcrowded or unhygienic environments through contaminated water, despite its brief survival outside the body.ColonizationOnce ingested, H. pylori enters the stomach and begins colonization by navigating through the mucus layer lining the stomach wall. It...
01:28Viral Hepatitis I: Introduction
Viral hepatitis is an inflammatory condition of the liver caused by infection with hepatotropic viruses, most commonly hepatitis A, B, C, D, and E. Despite variations in structure and transmission, all viruses mentioned infect hepatocytes and provoke immune responses that can hinder liver function. Additionally, some non-hepatotropic viruses can also lead to hepatic inflammation.Hepatitis A VirusHepatitis A virus (HAV) is transmitted through the fecal–oral route, typically by ingestion of food...
01:23Cirrhosis I: Introduction
Cirrhosis is a chronic, irreversible liver disease characterized by the widespread replacement of healthy liver tissue with fibrotic scar tissue and the formation of regenerative nodules.Etiology of cirrhosisCirrhosis results from sustained liver injury that triggers progressive fibrosis and structural remodeling. The underlying causes are diverse, encompassing common and less frequent clinical conditions. Regardless of the origin, all causes lead to chronic inflammation, hepatocyte loss, and...
01:24Cirrhosis II: Pathophysiology
Cirrhosis is a progressive chronic liver injury caused by prolonged inflammation, excessive fibrotic remodeling, and impaired regeneration. Over time, repeated hepatic insults disrupt the liver’s architecture and function, leading to reduced blood flow, impaired bile drainage, and diminished metabolic capacity.Pathophysiology of cirrhosisCirrhosis arises from three main responses to chronic liver damage: inflammation, immune activation, and hepatocyte death. These processes lead to structural...
01:25Chronic Pancreatitis I: Introduction
Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80% of...