在全球注册表中,接受置换治疗的儿科患者的功能性结局
Kristin J Dolan1, Katja M Gist2, Abby Basalely3
1Baylor College of Medicine, Texas Children's Hospital Houston, TX, USA.
概括
接受连续脏替代疗法 (CRRT) 的儿童在出院后往往会出现更糟糕的功能状态和新的疾病. 多学科的随访对于优化这些脆弱儿科患者的治疗结果至关重要.
科学领域:
- 儿科脏病学 儿科脏病学
- 关键护理医学 关键护理医学
- 临床结果研究研究
背景情况:
- 持续置换疗法 (CRRT) 改善了重症儿童的生存率,但与显著的发病率有关.
- 接受CRRT的儿科患者的功能结果需要进一步调查,以指导治疗后的护理.
- 功能状态量表 (FSS) 是一种工具,用于评估这一群体的功能结果.
研究的目的:
- 通过功能状态量表 (FSS) 评估接受CRRT的儿童的功能结果.
- 确定出院和随访期间新发病的发生率.
- 确定功能状态的预测因素和恢复对结果的影响.
主要方法:
- 从WE-ROCK国际多中心注册表中对CRRT的儿科患者 (出生至25岁) 的回顾性图表审查.
- 排除患有潜在脏疾病的患者,ECMO,以及未幸存者.
- 在医院出院时收集FSS数据,在出院后6个月和12个月.
主要成果:
- 在出院时,527名患者的FSS中位数为7,其中39%的功能状况恶化,18%获得新发病率.
- 释放时FSS的预测因素包括基线FSS,体重,并发症,机械通风和败血症.
- 在6个月后,387名患者的FSS中位数为6,其中10%获得了新的发病率. 排放FSS和伴随性疾病预测6个月FSS.
结论:
- 这是第一个大型的多中心研究,评估CRRT儿童的功能结果.
- 出院后的持续发病率凸显了全面评估和多学科后续行动的必要性.
- 在儿科CRRT幸存者中优化长期功能状态需要有针对性的干预和持续的护理.
相关概念视频
01:17Factors Affecting Renal Clearance: Renal Impairment
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Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
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01:27Dialysis
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01:11Renal Failure: Dose Adjustments
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In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
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However, dosage adjustments...
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However, dosage adjustments...
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01:28Renal Drug Excretion: Tubular Secretion
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01:45Kidney Structure
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01:23Renal Clearance
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