MTHFR基因与2型糖尿病的关联:一个病例对照研究和元分析
Qian Huang1,2, WeiWei Chang3, YuanYuan Wang4
1Tongling People's Hospital, Tongling, China.
Public health genomics
|April 21, 2025
概括
在亚洲人中,MTHFR C677T基因变异增加了2型糖尿病 (T2DM) 风险,而A1298C变异没有显著的关联. 这表明MTHFR多态性对T2DM易感性的种族依赖性影响.
科学领域:
- 遗传学 是一个遗传学.
- 代谢疾病 代谢疾病
- 人口健康 人口健康
背景情况:
- 甲基酸酸减少酶 (MTHFR) 基因的遗传变异与2型糖尿病 (T2DM) 易感性有关.
- 之前的研究对MTHFR基因多态和T2DM风险之间的关联提出了相互矛盾的结果.
研究的目的:
- 研究MTHFR基因单核酸多态 (SNP),特别是C677T和A1298C,与T2DM的遗传易感性之间的关系.
- 进行元分析,评估MTHFR C677T多态和T2DM之间的关联.
主要方法:
- 进行了一项病例控制研究,以评估MTHFR多态 (C677T和A1298C) 和T2DM风险.
- 使用Stata 17.0软件对7项研究进行了元分析,以评估MTHFR C677T基因与T2DM的关联.
主要成果:
- 在病例控制研究中,MTHFR C677T多态 (rs1801133) 与T2DM风险增加显著相关 (OR = 1.605).
- 在对共变量进行调整后,没有发现MTHFR A1298C多态 (rs1801131) 与T2DM风险的显著关联.
- 分析显示,在衰退和等位基因模型中,C677T具有显著的异质性;在随机效应模型中,亚洲人 (OR = 2.27) 具有显著的关联性;在亚洲人 (OR = 2.27) 具有显著的关联性.
结论:
- MTHFR C677T多态可能会影响T2DM易感性,其影响可能取决于种族.
- 这些发现表明,MTHFR C677T多态和T2DM风险之间存在着显著的关联,特别是在亚洲人群中.
相关概念视频
Diabetes Mellitus: Type 2 and Gestational
2.1K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.1K
Genome-wide Association Studies-GWAS
12.3K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
12.3K
Diabetes Mellitus: Overview and Type I Subtype
2.3K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
2.3K
Pathophysiology of Diabetes
839
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
839
Human Genetics
510
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
510
Diabetes: Symptoms, Diagnosis, and Complications
495
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
495


