刺激性肠综合征中饮食干预的有效性:系统性审查和网络元分析
Melanie S Cuffe1, Heidi M Staudacher2, Imran Aziz3
1Leeds Gastroenterology Institute, St James's University Hospital, Leeds, UK; Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, UK.
The lancet. Gastroenterology & hepatology
|April 21, 2025
概括
刺激性肠综合征 (IBS) 的饮食干预措施的有效性各不相同. 减少粉和减少糖的饮食似乎对全球IBS症状最有希望,而低FODMAP饮食也显示出对特定症状的好处.
科学领域:
- 胃肠病学 胃肠病学
- 营养科学 营养科学
- 基于证据的医学基于证据的医学.
背景情况:
- 刺激性肠综合征 (IBS) 管理通常涉及饮食干预.
- 不同饮食对IBS症状控制的比较有效性尚未得到充分证实.
研究的目的:
- 对各种饮食干预措施对控制IBS症状的相对有效性进行系统的审查和网络元分析.
主要方法:
- 在多个数据库中搜索随机对照试验 (RCT),将饮食干预与对照组进行比较.
- 根据全球IBS症状,腹痛,胀气和肠道习惯来评估有效性.
- 使用随机效应模型,并根据P分数对干预措施进行排名,以确定有效性.
主要成果:
- 减少粉和减少糖的饮食显示在改善全球IBS症状方面排名最高 (RR 0.41).
- 低FODMAP饮食对全球症状 (RR 0.51),腹痛 (RR 0.61) 和胀气 (RR 0.55) 有效.
- 在大多数比较中,信心是低到非常低的,除了低FODMAP和低粉/低糖饮食与习惯饮食 (中等信心).
结论:
- 虽然低FODMAP饮食对IBS有最多的证据,但其他新兴的饮食疗法需要进一步研究.
- 减少粉和减少糖的饮食显示出对全球IBS症状改善的重大前景.
相关概念视频
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
291
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
291
01:30Irritable Bowel Syndrome III: Medical and Nursing Management
135
Managing Irritable Bowel Syndrome (IBS) involves a multifaceted approach, including lifestyle modifications, dietary changes, and medication.
135
01:17Drugs for Treatment of Diarrhea-Predominant IBS
134
Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
134
01:21Drugs for Treatment of Constipation-Predominant IBS
124
Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
124
01:30Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
104
Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
104
01:17Irritable Bowel Syndrome I: Introduction
215
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
215