在美国老年人中,, parabens, phthalates 和认知功能的混合暴露之间的关联
Huidi Du1, Qingxia Wang1, Yiru Chen1
1Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin, Heilongjiang Province, China.
Journal of affective disorders
|April 21, 2025
概括
暴露于,和酸盐 (PAE) 与老年男性的认知功能较差有关. 这项研究强调了这些常见的环境化学物质对老年人认知能力下降的影响.
科学领域:
- 环境健康 环境健康
- 神经科学是一个神经科学.
- 老年学是一门学科.
背景情况:
- 认知功能下降是老年人群的一个主要问题.
- ,和酸盐 (PAE) 是常见的环境化学物质,可以干扰神经信号传递.
- 老年人特别容易受到环境暴露对健康的不利影响.
研究的目的:
- 调查混合暴露于,和PAE与美国老年人的认知功能之间的关联.
- 识别导致认知障碍的特定化学物质.
- 为公共卫生政策提供有关环境化学物质暴露的信息.
主要方法:
- 利用了856名参与国家健康和营养检查调查 (NHANES) (2011-2014) 的数据.
- 采用了通用线性 (GLM),加权量子素和 (WQS) 和贝叶斯内核机器回归 (BKMR) 模型.
- 在四个认知测试中评估了混合PAE和标准化z分数之间的关联.
主要成果:
- 使用WQS回归,男性的IRT测试中 (OR: 1.77,95%CI: 1.04-3.02) 暴露于, parabens和PAE的混合暴露与较低的得分有关.
- 在合并的风险中,MEHP显示出最重要的贡献.
- BKMR模型表明,在男性的IRT,DSST和全球认知测试中,混合暴露和认知障碍之间存在正相关性.
结论:
- 暴露于,和PAE可能会对老年人,特别是男性的认知功能产生负面影响.
- 混合化学物质暴露与认知测试的表现下降有关.
- MEHP被确定为这一群体认知衰退的主要贡献者.
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