在牛皮等疾病中,p62的性别特异性抗炎作用
Kamil Mieczkowski1, Latifa Bakiri2, Johannes Griss3
1Laboratory Genes and Disease, Department of Dermatology, Medical University of Vienna (MUW), Vienna, Austria.
The Journal of investigative dermatology
|April 21, 2025
概括
在缺乏SQSTM1/p62蛋白质的男性中,牛皮病恶化,揭示了p62在这种慢性皮肤疾病中具有性别特异的抗炎作用.
科学领域:
- 皮肤病学 皮肤病学
- 免疫学 免疫学 免疫学
- 分子生物学分子生物学
背景情况:
- 牛皮是一种慢性炎症性皮肤疾病,具有复杂的免疫和表皮细胞相互作用.
- 牛皮常常会出现系统性问题,如牛皮性关节炎.
- 在牛皮皮肤中,调节自,分化和炎症的蛋白质SQSTM1/p62升高.
研究的目的:
- 调查SQSTM1/p62在牛皮类表型中的作用.
- 在小鼠模型中分析p62缺乏对皮肤和关节炎症的影响.
主要方法:
- 使用一种具有可诱导c-Jun和JunB (DKO*) 表皮无活化的小鼠模型.
- 交叉DKO*小鼠与p62淘汰赛小鼠 (p62-/-) 产生DKO* p62-/-小鼠.
- 分析了皮肤和关节的表型,专注于性别特异性差异.
主要成果:
- 与其他组相比,雄性DKO* p62-/-小鼠表现出严重的皮肤和关节疾病.
- 雄性DKO* p62-/-小鼠的皮肤表现出表皮变厚,质细胞分化受损,免疫细胞透增加,CXCL1.1升高.
- 在雄性DKO* p62-/-小鼠皮肤中观察到增加的雄激素受体信号,炎症酶活性和KEAP1/NRF2通路激活.
结论:
- SQSTM1/p62在类似牛皮的疾病中起到性别特异的抗炎作用.
- 雄激素信号传递和炎症酶激活有助于在缺乏p62.2的男性中疾病恶化.
- 研究结果表明p62的作用可能对牛皮治疗具有临床意义.
相关概念视频
T Cell Types and Functions
617
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
617
EPS and iPS Cells in Disease Research
2.7K
Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
2.7K
Abnormal Proliferation
4.3K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.3K
Pleiotropy
37.9K
Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...
37.9K
NF-κB-dependent Signaling Pathway
7.2K
The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The...
NF-κB-dependent Signaling Mechanism
The...
7.2K


