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直接压缩的曼尼托:生产,功能,关键材料属性和共同加工的辅助剂.

Lijun Lin1, Xiao Lin2, Lan Shen3

  • 1Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine of Ministry of Education, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, PR China.

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概括

曼尼托尔是直接压缩 (DC) 片剂的关键制药辅助剂,因为它具有有益的特性. 了解其关键材料属性 (CMA) 和共同加工的形式对于提高平板电脑质量至关重要.

关键词:
共同加工的辅助剂 辅助剂关键材料属性 关键材料属性关键的质量属性是关键的质量属性.直接压缩直接压缩.曼尼托尔 (Mannitol) 是一种有毒的药物.从设计开始的质量.药片 药片 药片 药片 是一种药片.

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科学领域:

  • 制药科学 制药科学
  • 材料科学 材料科学 材料科学
  • 化学工程是化学工程的重要组成部分.

背景情况:

  • 曼尼托尔越来越多地被用于制药配方中的乳糖替代品,特别是用于药片.
  • 它的水溶性,低湿度和化学惰性等特性使其适用于各种剂型.
  • 直接压缩 (DC) 片剂提供了一种高效的制造工艺,而曼尼托尔是该领域的关键辅助剂.

研究的目的:

  • 为了回顾曼尼托尔用于直接压缩 (DC) 片剂的最新进展.
  • 探索曼尼托尔在药片配方中的功能,并确定潜在的关键材料属性 (CMA).
  • 讨论基于曼尼托尔的联合加工辅助剂及其对粒子特性的影响.

主要方法:

  • 文献综述侧重于DC片剂中曼尼托尔的最新研究和开发.
  • 对曼尼托的物理化学特性进行分析,这些特性与药片的性能有关.
  • 检查对曼尼托尔应用的共同加工技术及其结果.

主要成果:

  • 曼尼托尔的特性非常适合DC片剂,比其他辅助剂提供优势.
  • 识别曼尼的关键关键材料属性 (CMA) 对于稳定的药片质量至关重要.
  • 联合加工曼尼托尔可以增强其特性,从而改善平板电脑的特性.

结论:

  • 曼尼托尔是直接压缩 (DC) 片剂的宝贵辅助剂,其特性对配方成功至关重要.
  • 对关键材料属性 (CMA) 和联合加工的曼尼托尔衍生物的进一步研究将推动平板电脑制造业的创新.
  • 本综述为优化药物开发中曼尼托尔利用提供了一个参考.