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在用免疫检查点抑制剂治疗的固体瘤患者中,循环免疫反应的与年龄相关的分歧

Chester Kao¹, Soren Charmsaz¹, Hua-Ling Tsai¹

¹Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Nature communications

|April 21, 2025

概括

老年癌症患者对免疫检查点抑制剂 (ICI) 的反应类似,但显示出明显的免疫细胞变化. 了解这些与年龄相关的免疫差异可以帮助量身定制癌症免疫疗法.

科学领域:

免疫学免疫学免疫学
在瘤学瘤学.
老年病的医生老年病的医生

背景情况:

癌症发病率随着年龄的增长而增加,影响65岁以上的人.
免疫系统的组成和功能随着年龄的增长而发生变化.
衰老对免疫检查点抑制剂 (ICI) 反应的影响尚未完全理解.

研究的目的:

对ICI癌症治疗的免疫反应的年龄相关差异进行调查.
分析接受ICI的老年癌症患者与年轻癌症患者的免疫表型.

主要方法:

来自104名接受ICI治疗的癌症患者的血液样本的前性分析.
利用多重细胞因子测定和高参数质量细胞计.
将患者分层分为老年人 (≥65岁) 和年轻人.

主要成果:

老年人和年轻的患者在ICI治疗时表现出类似的临床结果.
在老年和年轻患者之间观察到基线免疫表型的显著差异.
老年患者表现出细胞因子反应减弱和天真T细胞减少,免疫检查点分子表达增加.
年龄较大组的受试者与非受试者相比,表现出更强大的T细胞扩张.

结论:

根据年龄分层的免疫简介提供了对ICI治疗的不同反应的见解.
老年患者的免疫表型在ICI治疗期间持续存在.
适合年龄的免疫治疗策略可能会提高老年人治疗的疗效.

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