相关实验视频

Updated: May 10, 2025

Utilizing a Comprehensive Immunoprecipitation Enrichment System to Identify an Endogenous Post-translational Modification Profile for Target Proteins
08:12

Utilizing a Comprehensive Immunoprecipitation Enrichment System to Identify an Endogenous Post-translational Modification Profile for Target Proteins

Published on: January 8, 2018

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针对NRF2的表观遗传和翻译后修改:疾病治疗中的关键调节因素

Xinyi Yang1, Yingchao Liu1, Jinghao Cao1

  • 1Laboratory Medicine Center, Department of Clinical Laboratory, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, 310014, China.

Cell death discovery
|April 21, 2025
PubMed
概括

核因素红色素2相关因子2 (NRF2) 调节细胞对抗氧化应激的防御. 这项研究详细介绍了翻译后修改和表观遗传变化如何控制NRF2,为治疗癌症和神经退行等疾病提供了洞察力.

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The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
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