Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

The Tumor Microenvironment02:17

The Tumor Microenvironment

6.5K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.5K
Tumor Immunotherapy01:27

Tumor Immunotherapy

441
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
441

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

CRR-Net: a correlation reconstruction and refinement network for deformable medical image registration.

Visual computing for industry, biomedicine, and art·2026
Same author

Maternal trans-vaccenic acid shapes neonatal T cell development and early-life immune imprinting.

Science (New York, N.Y.)·2026
Same author

Increasing intrinsic protein disorder improves CD8+ immunogenicity for a SARS CoV2 vaccine candidate antigen.

Molecular therapy : the journal of the American Society of Gene Therapy·2026
Same author

Randomized Trial of Two Fractionation Schedules of Myeloablative Busulfan with Fludarabine and Cladribine in Acute Myeloid Leukemia or Myelodysplastic Syndromes.

Transplantation and cellular therapy·2026
Same author

ATR kinase inhibitors induce mitochondrial fission in CD8<sup>+</sup> T cells and impair immune memory <i>in vivo</i>.

bioRxiv : the preprint server for biology·2026
Same author

Coincident epithelial signals restrain commensal-specific CD8αβ<sup>+</sup> T cells in the intestine.

bioRxiv : the preprint server for biology·2026

相关实验视频

Updated: May 17, 2025

Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports
07:44

Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports

Published on: November 28, 2019

7.4K

瘤间歇性液体丰富的甲胺抑制T细胞功能.

Yupeng Wang1, Drew Wilfahrt2,3, Patrick Jonker4

  • 1Tsinghua Medical School, Beijing, China.

Nature cell biology
|April 21, 2025
PubMed
概括

瘤营养压力会损害抗瘤免疫力. 研究人员发现瘤液中的甲胺 (pEtn) 通过破坏信号传输来阻碍T细胞功能,突出显示pEtn是改善癌症免疫力的目标.

更多相关视频

Enrichment and Characterization of the Tumor Immune and Non-immune Microenvironments in Established Subcutaneous Murine Tumors
08:32

Enrichment and Characterization of the Tumor Immune and Non-immune Microenvironments in Established Subcutaneous Murine Tumors

Published on: June 7, 2018

9.5K
Evaluation of Tumor-infiltrating Leukocyte Subsets in a Subcutaneous Tumor Model
07:49

Evaluation of Tumor-infiltrating Leukocyte Subsets in a Subcutaneous Tumor Model

Published on: April 13, 2015

20.0K

相关实验视频

Last Updated: May 17, 2025

Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports
07:44

Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports

Published on: November 28, 2019

7.4K
Enrichment and Characterization of the Tumor Immune and Non-immune Microenvironments in Established Subcutaneous Murine Tumors
08:32

Enrichment and Characterization of the Tumor Immune and Non-immune Microenvironments in Established Subcutaneous Murine Tumors

Published on: June 7, 2018

9.5K
Evaluation of Tumor-infiltrating Leukocyte Subsets in a Subcutaneous Tumor Model
07:49

Evaluation of Tumor-infiltrating Leukocyte Subsets in a Subcutaneous Tumor Model

Published on: April 13, 2015

20.0K

科学领域:

  • 免疫学 免疫学 免疫学
  • 癌症生物学 癌症生物学
  • 代谢学 代谢学 代谢学

背景情况:

  • 瘤微环境中的营养压力是抗瘤免疫力的重要障碍.
  • 瘤间歇性液中含有可以抑制免疫细胞功能的代谢物.
  • 从其他抑制因素中分离营养压力的影响是很有挑战性的.

研究的目的:

  • 为了研究瘤营养应激对CD8+T细胞功能的孤立影响.
  • 为了确定在瘤微环境中负责T细胞功能障碍的特定代谢物.
  • 评估针对已识别的代谢物增强抗瘤免疫力的治疗潜力.

主要方法:

  • 开发了一种化学定义的介质 (TIFM),模仿瘤间歇性液体代谢.
  • 在TIFM中培养CD8+T细胞,以评估扩张和效应器功能.
  • 确定了甲胺 (pEtn) 作为一个关键的代谢物驱动T细胞功能障碍.
  • 分析了pEtn介导的T细胞抑制的机制,重点关注T细胞受体信号传递和二甲醇耗尽.
  • 评估了减少pEtn积累对内T细胞功能和瘤控制 in vivo的影响.

主要成果:

  • 在TIFM中培养CD8+T细胞导致了有限的扩张和受损的效应器功能.
  • 甲胺 (pEtn) 被确定为T细胞功能障碍的主要驱动因素.
  • pEtn通过耗尽对信号转导至关重要的二甲酸甘油来抑制T细胞受体信号传递.
  • 减少瘤中的pEtn积累增强了瘤内T细胞功能,改善了瘤控制.

结论:

  • 瘤营养压力本身就足以诱导T细胞功能障碍.
  • 酸乙胺 (pEtn) 在瘤中的积累在免疫抑制中起着主导作用.
  • 向pEtn积累是一个有希望的策略,可以增强抗瘤免疫力并改善癌症治疗结果.