一个扩展的代谢途径,用于由共生细菌产生雄激素
Taojun Wang1,2, Saeed Ahmad3,4, Angélica Cruz-Lebrón5
1Department of Animal Sciences, University of Illinois Urbana-Champaign, Urbana, IL, USA.
Nature microbiology
|April 21, 2025
概括
肠道和尿道细菌产生雄激素,影响前列腺癌的生长和阿比拉治疗反应. 像desF这样的微生物基因是这个过程的关键.
科学领域:
- 微生物学 微生物学
- 内分泌学 在内分泌学.
- 癌症生物学 癌症生物学
背景情况:
- 共生细菌会影响宿主类固醇激素,包括雄激素.
- 对于雄激素生产的微生物途径在很大程度上仍然没有特征.
研究的目的:
- 确定参与雄激素合成的微生物基因.
- 研究微生物雄激素在前列腺癌和药物代谢中的作用.
主要方法:
- 在Clostridium scindens中确定了微生物基因desF,可催化androstenedione转化为表.
- 在实验室中评估了Epitestosterone对前列腺癌细胞增殖的影响.
- 在前列腺癌患者的便中分析了desF水平.
- 在尿路细菌中检测到17β-hydroxysteroid脱酶活性 (desG).
- 研究了细菌对皮质醇和普得尼松的转化为雄激素.
主要成果:
- 乙激素促进了依赖于雄激素受体的前列腺癌细胞增殖.
- 便中升的desF水平与对阿比拉特/普雷迪尼松疗法的不响应相关.
- 尿路细菌产生雄激素,并通过皮质醇/普雷尼松代谢促进前列腺癌细胞的生长.
- 细菌脱酶 (DesAB) 不被阿比拉抑制,与宿主CYP17A1.1不同.
结论:
- 微生物基因 (desF,desG) 在肠道和泌尿道中促进雄激素的产生.
- 细菌的雄激素发生在前列腺癌的进展和对内分泌治疗的耐药性方面发挥着作用.
- 准细菌类固醇代谢可能为前列腺癌提供新的治疗策略.
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