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Updated: May 10, 2025

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溶解体EGFR作为Rheb-GEF独立于其激酶活性来激活mTORC1的作用

Xiaobo He1, Qiu-Xia Wang1, Denghui Wei2

  • 1Sun Yat-sen University Cancer Center, Guangdong Provincial Clinical Research Center for Cancer, State Key Laboratory of Oncology in South China, Guangzhou, Guangdong, China.

Cell research
|April 21, 2025
PubMed
概括

皮表皮生长因子受体 (EGFR) 具有一种新的激酶独立功能,通过结合Rheb.激活mTORC1. 针对这种机制,与激酶活性一起,提供了一个有前途的癌症治疗策略.

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