周水道灰色部分的SST神经元调节排尿和膀功能.
Junan Yan1,2,3, Ziyan Gao4, Xianping Li5,6
1Center for Neurointelligence, School of Medicine, Chongqing University, Chongqing, China. junan_yan@aliyun.com.
Communications biology
|April 21, 2025
概括
科学家在周水管灰 (PAG) 中确定了表达索马托斯坦素 (SST) 的神经元,这些神经元控制尿动. 激活这些神经元会触发排尿,而抑制它们会停止排尿,揭示了膀控制的关键途径.
科学领域:
- 神经科学是一个神经科学.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 生理学 生理学 生理学
背景情况:
- 排尿是一个复杂的生理过程,由中枢神经回路控制.
- 周水管灰 (PAG) 是已知的排尿控制中心,但涉及的特定神经元类型尚未明确定义.
研究的目的:
- 为了确定侧向和腹向PAG (l/vlPAG) 中的特定神经元亚型,这些亚型调节了排尿过程.
- 阐明从l/vlPAG.来源于排尿控制中的神经通路.
主要方法:
- 在l/vlPAG中识别体静止素 (SST) 表达神经元.
- 在自由移动的动物中,在排尿时记录神经元活动.
- 光遗传激活和抑制SST表达神经元.
- 调查到庞丁性排尿中心 (PMC) 的投影和盆腔神经切割后的影响.
主要成果:
- 在l/vlPAG中的SST表达神经元显示与排尿开始相关的活性.
- 这些神经元的光遗传激活诱导了排尿和膀收缩.
- 这些神经元的抑制抑制了持续的排尿.
- 激活向PMC投射的l/vlPAG SST+神经元触发了排尿,这种效应取决于骨盆神经.
结论:
- l/vlPAG SST表达神经元是排尿的关键调节者.
- 这些神经元通过PAG-PMC通路控制排尿.
- 这项研究为膀控制机制和尿路功能障碍的潜在治疗点提供了新的见解.
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