在功能完整的老年人中,血压指标与大脑衰老的液体生物标志物之间的关系
Anna M VandeBunte1,2, Bailey L Ortiz1,2, Emily W Paolillo1
1Memory and Aging Center, Department of Neurology, University of California, San Francisco, 675 Nelson Rising Lane, Suite 190, San Francisco, CA, 94158, USA.
Alzheimer's research & therapy
|April 21, 2025
概括
脉压升高,即血压的衡量标准,与老年人中与痴呆相关的生物标志物的较高水平有关. 控制血压,特别是脉压,可能有助于降低痴呆风险并支持大脑健康.
科学领域:
- 神经科学是一个神经科学.
- 心血管健康 心血管健康
- 生物标志物研究 生物标志物研究
背景情况:
- 心血管健康显著影响痴呆风险,高血压是大脑衰老的主要因素.
- 血液生物标志物如pTau181,Aβ42/40,NfL和GFAP有助于了解痴呆症,但它们与特定血压指标的联系需要进一步探索以进行个性化预防.
- 这项研究调查了各种血压指标和与神经退行症和阿尔茨海默病病理学相关的关键血生物标志物之间的关联.
研究的目的:
- 为了检查不同血压指标 (透气,收缩,脉压) 和血生物标志物 (pTau181,Aβ42/40,NfL,GFAP) 之间的关系.
- 探索这些关联如何根据性别,年龄或APOE-ε4状态而有所不同.
- 通过将心血管健康指标与大脑衰老的分子标志物联系起来,为个性化的痴呆症预防策略提供信息.
主要方法:
- 109名认知完整的老年人接受了血生物标志物分析的血液抽取 (pTau181,Aβ42/40,NfL,GFAP).
- 实验室内血压测量包括透气,收缩和脉冲压.
- 回归模型评估生物标志物水平作为血压指标的函数,根据年龄和性别进行调整,相互作用模型探索差异效应.
主要成果:
- 较高的脉压与pTau181,NfL和GFAP水平的增加相关,但不是Aβ42/40.
- 压缩性血压升高与较高的pTau181相关,而压缩性血压没有显著的关联.
- 在女性的高脉压和高GFAP之间观察到明显更强的关联,在APOE-ε4载体中较低的Aβ42/40之间观察到更强的关联.
结论:
- 脉冲压升高,在较小程度上,缩血压与老年人中阿尔茨海默病和神经退行症标志物增加有关.
- 这些发现强调了控制血压,特别是脉冲压,对于降低痴呆风险的重要性.
- 将心血管健康数据与生物标志物信息相结合,可以增强个性化的痴呆症预防和管理方法.
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