局部皮质类固醇灌对鼻腔伤口愈合的影响
Jackson R Vuncannon1, Khaled A Altartoor1, Anastasia Kolousek2
1Emory University Department of Otolaryngology - Head and Neck Surgery, Emory University School of Medicine, Atlanta GA, USA.
American journal of rhinology & allergy
|April 22, 2025
概括
局部皮质类固醇在患有鼻多 (CRSwNP) 细胞的慢性鼻炎时稍微延迟了伤口关闭,但没有损害表皮屏障功能. 这些发现表明,内镜鼻手术 (ESS) 后24小时可以安全使用局部皮质类固醇.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 伤口愈合 治愈 伤口愈合
- 细胞生物学 细胞生物学
背景情况:
- 具有鼻息肉的慢性鼻炎 (CRSwNP) 通常需要手术和局部皮质类固醇.
- 皮质类固醇可以通过改变炎症来阻碍术后愈合.
- 评估局部皮质类固醇对鼻上皮质愈合的影响至关重要.
研究的目的:
- 评估布德索尼德对CRSwNP中鼻膜上皮质伤口愈合的影响.
- 为了确定局部皮质类固醇是否会影响皮质屏障功能在受伤后的恢复.
主要方法:
- 来自CRSwNP患者的初级人类鼻上皮细胞 (HNEC) 在空气-液体界面 (ALI) 培养.
- 一个伤试验模拟伤害,随后进行布索尼德治疗.
- 测量了伤口关闭时间和体电阻 (TEER).
主要成果:
- 与对照组 (12.3小时) 相比,受布塞索尼德治疗的HNEC患者 (15.1小时) 的伤口关闭显著延迟.
- 在两组中,所有伤口都在19小时内关闭.
- 没有观察到TEER恢复的显著差异,这表明屏障功能得到保护.
结论:
- 在CRSwNP中,局部布德索尼德会延迟上皮层伤口的关闭,但不会阻止愈合.
- 表皮屏障功能恢复不会受到布索尼德治疗的影响.
- 局部皮质类固醇可以安全地在内镜外科手术 (ESS) 后24小时开始使用.
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