探讨神经病对肺癌风险的影响:从介导的孟德尔随机化中获得的见解
Jie Zhang1, Xiao Ma1, Zhiyu Liu1
1Department of Oncology, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Brain and behavior
|April 22, 2025
概括
神经病症与患肺癌的风险更高有关,特别是在男性中. 教育成就可能会调解这种关联,建议潜在的干预策略.
科学领域:
- 精神病学和瘤学的精神病学.
- 遗传流行病学遗传流行病学
背景情况:
- 神经主义是一种性格特征,其特点是情绪不稳定,是各种健康状况的已知风险因素.
- 神经病症和肺癌风险之间的关系仍然不完全理解,需要进一步调查.
研究的目的:
- 通过使用孟德尔的随机化方法,调查神经病变和肺癌风险之间的潜在因果关系.
- 探索这种关联中的性别特异性差异以及教育成就的调解作用.
主要方法:
- 利用公开可用的全基因组关联研究 (GWAS) 数据对欧洲血统的个人.
- 采用双样本的门德尔随机化框架,使用单核酸多态 (SNPs) 作为神经病的工具变量.
- 应用逆方差权衡 (IVW),加权中位数,MR-Egger和加权模式统计方法.
主要成果:
- 确定了67个与神经病症有显著关联的SNP.
- 发现神经病症和肺癌风险增加之间存在显著的关联 (OR = 1.175,p = 0.026).
- 在男性和女性中观察到适度,显著的风险增加,男性的影响略大.
- 大约17%的关联是由教育程度介导的.
结论:
- 这项门德尔随机化研究提供了强有力的证据,证明神经病症和肺癌风险增加之间存在因果关系.
- 这种关联在男性中比女性更明显.
- 教育成就充当调解者,这表明改善教育的干预措施可能会降低与神经病症相关的肺癌风险.
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