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在评估HPV疫苗接种时,开发,验证和测试非疫苗可预防的人类乳头瘤病毒,以控制性行为的差异

Emily Dema¹, Jaimie Z Shing², Marta Checchi³

¹University College London, London, United Kingdom.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

|April 22, 2025

概括

非疫苗可预防的人类乳头瘤病毒 (NVP-HPV) 类型可以表明性行为. 在HPV疫苗影响研究中对NVP-HPV进行调整,证实了最初的有效性估计是强大的.

科学领域:

流行病学流行病学
病毒学病毒学
公共卫生公共卫生

背景情况:

评估人类乳头瘤病毒 (HPV) 疫苗接种的影响通常假定稳定的传播因素,这可能不是真的.
非疫苗可预防的HPV (NVP-HPV) 类型可以作为与性行为相关的分子指标.

研究的目的:

开发和验证NVP-HPV类型的分组作为性行为的代理.
评估NVP-HPV调整对HPV疫苗有效性估计的影响.

主要方法:

利用了来自全国性态度和生活方式调查 (Natsal-2和Natsal-3) 和英国HPV监测计划的数据.
验证了NVP-HPV类型 (26/53/66/70/73) 与自我报告的性行为之间的关联.
在不同人群和时间框架中计算了NVP-HPV调整后的HPV16/18疫苗影响估计.

主要成果:

感染NVP-HPV与性行为有很强的相关性,包括早期的性初恋年龄和更多的伴侣数量.
调整NVP-HPV并没有显著改变Natsal数据集中的疫苗影响估计.
在英格兰的监测数据中,NVP-HPV调整也维持了对HPV16/18的观察到的流行率,随着时间的推移,NVP-HPV流行率保持稳定.

结论:

确立了NVP-HPV作为性行为的可靠指标的概念证明.
证明对NVP-HPV进行调整证实了原始HPV疫苗有效性估计的稳定性.
在疫苗接种影响评估中,NVP-HPV可以成为控制传播风险变化的有价值工具.

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