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化疗对印度乳腺癌患者认知功能的急性和长期影响
Priti Singh1, Chaithanya Leon1, Simran Kaur1
1Stress and Cognitive Electroimaging Laboratory, Department of Physiology, All India Institute of Medical Sciences, New Delhi 110029, India.
Ecancermedicalscience
|April 22, 2025
概括
化疗显著损害了乳腺癌患者的认知功能,影响了长期的注意力和工作记忆. 这项研究强调了需要更好的化疗相关认知缺陷的管理策略.
科学领域:
- 在瘤学瘤学.
- 神经科学是一个神经科学.
- 心理学 心理学 心理学
背景情况:
- 乳腺癌 (BC) 是全球癌症发病率和死亡率的主要原因.
- 改善BC患者的生存率需要了解和管理化疗的副作用,特别是认知障碍.
- 认知功能障碍显著影响了BC幸存者的生活质量.
研究的目的:
- 调查化疗对BC患者认知功能的急性和长期影响.
- 为了比较化学疗法治疗的BC患者,化学疗法以前的BC患者和健康对照者的认知功能.
- 用主观,客观问卷和神经心理测试进行全面的认知评估.
主要方法:
- 一项涉及120名参与者的横截面研究:每位30名化学治疗前BC患者,化学治疗期间的患者,化学治疗后BC患者和健康对照.
- 使用印度语心理状态检查 (HMSE) 和FACT Cog V3进行主观认知评估.
- 使用阿登布鲁克认知检查-III (ACE-III) 和基于计算机的神经心理测试 (威斯康星州卡片排序测试,Flanker任务,n-back任务) 的客观认知评估.
主要成果:
- 与对照组相比,主观评估显示,化疗后患者 (HMSE) 的得分较低,化疗期间认知障碍较高 (FACT Cog V3).
- 客观评估显示,在化疗期间和化疗后组 (ACE-III) 的得分明显低于健康对照组.
- 神经心理测试表明,与化疗前和健康对照组相比,化疗后患者的注意力和工作记忆领域的准确性较低,反应时间较长.
结论:
- 化疗对乳腺癌患者的认知功能产生了急性和长期的负面影响.
- 认知缺陷,特别是注意力和工作记忆,在主观和客观评估中都很明显.
- 这些发现强调了解决化疗引起的认知障碍的重要性,以改善患者的生活质量.
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