相关实验视频

Updated: Jul 20, 2026

Identifying the Effects of BRCA1 Mutations on Homologous Recombination using Cells that Express Endogenous Wild-type BRCA1
08:53

Identifying the Effects of BRCA1 Mutations on Homologous Recombination using Cells that Express Endogenous Wild-type BRCA1

Published on: February 17, 2011

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哥伦比亚乳腺癌患者的生殖突变:BRCA3是否即将到来?

Lisa Ximena Rodríguez Rojas1,2, Liliana Doza Martínez1, Jorge Andrés Olave Rodríguez2

  • 1Fundación Valle del Lili, Servicio de Genética Humana, Cra 98 No. 18 - 49, Cali 760031, Colombia.

Ecancermedicalscience
|April 22, 2025
PubMed
概括

在哥伦比亚,遗传性乳腺癌的生殖基因突变是多样化的,超越BRCA1/BRCA2. 这项研究强调了哥伦比亚乳腺癌患者非BRCA基因的重要性.

关键词:
这是一个ATMATMATM.这就是BRCA1的原因.这就是BRCA2的原因.这就是BRCA3的原因.细菌突变是细菌的突变.遗传性乳腺癌是一种遗传性乳腺癌.多基因面板的组件.

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Mismatch Repair01:36

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Overview
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Cancers Originate from Somatic Mutations in a Single Cell

Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
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Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Mismatch Repair01:20

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The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...
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Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
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Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...