噪音引起的感觉神经听力损失和高血压之间的相互作用:病理生理机制和治疗前景
Carola Y Förster1, Sergey Shityakov2, Stavros Stavrakis3
1Department of Anesthesiology, Intensive Care, Emergency and Pain Medicine, University Hospital Würzburg, Würzburg, Germany.
Frontiers in cellular neuroscience
|April 22, 2025
概括
噪音引起的听力损失 (NIHL) 破坏了血液迷宫屏障 (BLB),导致严重的健康问题. 先进的计算和基于矢量的策略显示出治疗NIHL及其相关条件的前景.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 感觉神经听力损失 (SNHL) 影响全球人口的5%以上,噪音引起的听力损失 (NIHL) 是一个重要的贡献者.
- NIHL改变了血液迷宫屏障 (BLB) 的生理学,增加了透性,并与心血管问题,高血压和糖尿病等系统性疾病联系起来.
研究的目的:
- 为NIHL提供全面的概述,详细介绍其病理生理学,对BLB的影响以及相关的并发症.
- 探索新兴的治疗策略,包括神经调节和基于矢量的方法,用于管理和预防NIHL.
主要方法:
- 审查关于NIHL病理生理学的现有文献及其对听觉系统结构的影响.
- 探索用于药物发现和优化的计算方法 (分子对接,模拟,AI / ML,网络药理学).
- 分析神经调节和基于载体的策略,以克服像BLB这样的生物障碍.
主要成果:
- NIHL导致BBL完整性和功能发生显著变化.
- 计算方法显示了识别和优化针对BLB传送器的治疗剂的潜力.
- 神经调节和基于载体的策略为治疗开发提供了新的途径.
结论:
- NIHL是一种复杂的疾病,具有深远的系统性健康影响.
- 创新的计算和基于矢量的治疗策略有望克服NIHL治疗中的BLB挑战.
- 对这些先进方法的进一步研究对于有效的NIHL管理和预防至关重要.
相关概念视频
01:18Neural Regulation of Blood Pressure
2.5K
The neural regulation of blood pressure involves intricate interactions between the autonomic nervous system (ANS) and cardiovascular system, ensuring adequate perfusion of tissues. This regulation primarily occurs through baroreceptor and chemoreceptor reflexes, involving both short-term and long-term mechanisms.
Baroreceptor Reflex
Baroreceptors, located in the carotid sinuses and aortic arch, detect changes in blood pressure. When blood pressure rises, these stretch-sensitive receptors...
Baroreceptor Reflex
Baroreceptors, located in the carotid sinuses and aortic arch, detect changes in blood pressure. When blood pressure rises, these stretch-sensitive receptors...
2.5K
01:18Hypertension and Regulation of Blood Pressure
1.8K
Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
1.8K
01:31Hearing
51.1K
When we hear a sound, our nervous system is detecting sound waves—pressure waves of mechanical energy traveling through a medium. The frequency of the wave is perceived as pitch, while the amplitude is perceived as loudness.
51.1K
01:26Heart Failure Drugs: Inhibitors of Renin-Angiotensin System
305
The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
305
01:18Disorders of the Autonomic Nervous System
466
The autonomic nervous system (ANS) is an intricate network of nerves that controls functions such as the regulation of heart rate, digestion, and blood pressure regulation. When this system malfunctions, it can lead to various disorders that affect multiple bodily functions. One common feature of many autonomic disorders is the involvement of smooth blood vessels, which play a crucial role in regulating blood flow throughout the body.
Raynaud's disease, also known as Raynaud's...
Raynaud's disease, also known as Raynaud's...
466
01:30Blood Pressure
908
Blood pressure (BP) is the pressure or force of blood exerted on the artery's walls as it circulates through the body. It is essential for maintaining blood flow throughout the body.
The average BP in an adult is typically around 120/80 mmHg (millimeters of mercury). In this measurement, the numerator (120) indicates the systolic pressure, which is the pressure in the arteries during the contraction of the heart's ventricles as blood is expelled. The denominator (80) represents the...
The average BP in an adult is typically around 120/80 mmHg (millimeters of mercury). In this measurement, the numerator (120) indicates the systolic pressure, which is the pressure in the arteries during the contraction of the heart's ventricles as blood is expelled. The denominator (80) represents the...
908