相关实验视频

Updated: May 10, 2025

Using Retinal Imaging to Study Dementia

Using Retinal Imaging to Study Dementia

Published on: November 6, 2017

在老年患者中,视网膜层厚度和术后妄想之间存在关联

Zhongyong Shi^1,2, Xin Ma³, Tianyi Tang⁴

¹Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

General psychiatry

|April 22, 2025

概括

右眼的较厚的手术前黄斑厚度与老年人手术后痴呆症的风险和严重程度更高有关. 这一发现表明,黄斑厚度可能是潜在的非侵入性生物标志物,用于妄想脆弱性.

科学领域:

眼科医生眼科眼科
老年医学老年医学
神经科学是一个神经科学.

背景情况:

手术后痴呆症是老年手术患者常见的并发症,原因和生物标志物不明.
视网膜层厚度与阿尔茨海默病等疾病中的认知功能有关.
在患有术后妄想症的患者中,对视网膜层厚度的研究有限.

研究的目的:

为了研究视网膜层厚度和手术后痴呆症在接受手术的老年人之间的关系.
探索潜在的非侵入性生物标志物来预测妄想风险和严重程度.

主要方法:

对169名接受选择性手术的参与者 (≥65岁) 的横截面研究.
手术前的斑点厚度和周围毛囊视网膜神经纤维层 (RNFL) 厚度,通过光学连贯断层扫描 (OCT) 测量.
使用混乱评估方法 (CAM) 和CAM-严重性 (CAM-S) 评估的术后妄想.

主要成果:

40名 (24%) 参与者出现了术后妄想.
较厚的手术前右黄斑厚度与 Delirium 的更高发病率 (OR 1.593) 和严重程度 (β=0.256) 有显著的关联.
对于左黄斑或双边周囊RNFL厚度没有发现显著的关联.

结论:

在老年手术患者中,手术前的斑点厚度可能表明患上术后狂妄的脆弱性.
斑点厚度可以作为潜在的非侵入性生物标志物.
需要进一步的大规模研究来验证这些发现.

关键词:

跨部门研究跨部门研究老年精神病学是一门精神病学专业.

更多相关视频

An Alternative and Validated Injection Method for Accessing the Subretinal Space via a Transcleral Posterior Approach

An Alternative and Validated Injection Method for Accessing the Subretinal Space via a Transcleral Posterior Approach

Published on: December 7, 2016

Determining Gender-Based Differences in Retinal and Choroidal Thickness in Underweight Individuals via Swept-Source Optical Coherence Tomography

Determining Gender-Based Differences in Retinal and Choroidal Thickness in Underweight Individuals via Swept-Source Optical Coherence Tomography

Published on: December 1, 2023

相关概念视频

Photoreceptors and Visual Pathways

Photoreceptors and Visual Pathways

At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...