儿童呼吸道感染的变化COVID-19大流行前后的变化
Yuanyuan Yue1,2, Dan Wu1,2, Qian Zeng1,2
1Clinical Laboratory, Children's Hospital Affiliated to Shandong University, Jinan, China.
Frontiers in cellular and infection microbiology
|April 22, 2025
概括
在COVID-19期间的非药物干预 (NPI) 影响了儿童急性呼吸道感染 (ARI) 病原体的流行. 流行后,许多ARI病原体的发病率增加,这表明由于NPI释放和免疫力降低而复苏.
科学领域:
- 儿童传染病 儿童传染病
- 流行病学 流行病学
- 公共卫生干预措施 公共卫生干预措施
背景情况:
- 非药物干预 (NPI) 在COVID-19大流行期间显著改变了急性呼吸道感染 (ARI) 病原体流行率的格局.
- 了解这些变化对于管理儿科呼吸系统健康至关重要.
研究的目的:
- 分析COVID-19大流行之前,期间和之后儿童中13种常见的ARI病原体的流行率的变化.
- 评估NPI对儿科呼吸道病原体循环的长期影响.
主要方法:
- 在2018年1月至2024年1月期间,收集了337310个临床样本的实时PCR数据.
- 病原体流行率在三个时期进行了比较:流行病前,流行病期间和流行病后.
主要成果:
- 流行病期间,A型流感 (流感A), Mycoplasma pneumoniae (MP),Adenovirus (ADV),Streptococcus pneumoniae (SP),Haemophilus influenzae (HI),Staphylococcus aureus (SA) 和Klebsiella pneumoniae (KPN) 等特定病原体的数量有所减少,而B型流感 (流感B) 和Pseudomonas aeruginosa (PAE) 的数量则有所增加.
- 在大流行后,流感A,ADV,呼吸道共囊病毒 (RSV),犀利病毒 (RhV),SP,HI,KPN,PAE和SA的发病率上升,而MP,流感B和偏流感病毒 (PIV) 的发病率下降.
结论:
- NPIs有效地中断了许多ARI病原体的传播.
- 取消NPI,加上人口免疫力下降,可能有助于在儿童中观察到某些ARI病原体的复苏.
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