时间优化疫苗的使用:系统性审查和元分析
Koen Vink1, Johannes Kusters2, Jacco Wallinga1,3
1Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, Netherlands.
Frontiers in public health
|April 22, 2025
概括
早晨接种疫苗可以促进抗体反应,特别是在老年人中. 优化疫苗接种时间可能会提高对老年人等关键人口群体的有效性,为改善公共卫生结果提供一种简单的策略.
科学领域:
- 免疫学 免疫学 免疫学
- 时间生物学 时间生物学
- 公共卫生 公共卫生
背景情况:
- 新出现的证据表明,接种疫苗的一天中的时间可以影响免疫反应.
- 本系统性审查旨在巩固关于疫苗接种时间对免疫反应影响的研究.
- 该研究评估了优化疫苗接种计划以提高计划有效性的潜力.
研究的目的:
- 提供关于疫苗接种时间如何影响免疫反应的全面概述.
- 评估疫苗接种时间在优化疫苗接种计划中的作用.
- 通过元分析量化疫苗接种时间对抗体反应的影响.
主要方法:
- 在Embase,Medline和Scopus进行了系统的文献搜索.
- 包括的研究是观察性和临床试验,评估人类在不同时间对疫苗接种的免疫反应.
- 一项元分析侧重于临床试验,以确定疫苗接种时间对抗体反应的影响大小.
主要成果:
- 确定了17项关于COVID-19,流感,乙型肝炎,甲型肝炎和肺炎球菌疫苗的研究.
- 11项研究显示,接种疫苗的时间对抗体反应有显著影响,10项研究支持早上接种疫苗.
- 在60岁以上的成年人中,早晨接种疫苗产生了更强的抗体反应,特别明显在接种流感疫苗的人中 (SMD=0.32在65岁以上).
结论:
- 早晨接种疫苗可以提高60岁及以上的成年人的抗体反应.
- 这种人口结构对于流感和COVID-19疫苗接种策略至关重要.
- 时间优化疫苗施用是一种低风险,具有成本效益的方法,可以提高老年人疫苗的有效性.
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