SIAE介导的酸乙化损失有助于性结肠炎
Siyue Bo1, Xiaotong Wang1,2,3, Jiani Qian1,4
1Center for Clinical Mass Spectrometry, College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu, 215123, People's Republic of China.
Journal of inflammation research
|April 22, 2025
概括
酸乙化酶 (SIAE) 在性结肠炎 (UC) 中被上调,降低酸水平并破坏粘膜屏障. 这表明SIAE是UC的关键因素,也是潜在的治疗目标.
科学领域:
- 胃肠病学 胃肠病学
- 分子生物学分子生物学
- 免疫学 免疫学 免疫学
背景情况:
- 性结肠炎 (UC) 损害了结肠的粘液层,增加了对细菌入侵和炎症的敏感性.
- 糖化,特别是酸修饰,对于肠道屏障功能至关重要.
- 酸乙化和酸乙化酶 (SIAE) 在UC病变发生中的作用需要进一步研究.
研究的目的:
- 调查酸去乙化在性结肠炎 (UC) 进展中的作用.
- 探索酸乙雌激酶 (SIAE) 在UC病变发生中的功能.
主要方法:
- 分析UC患者和结直肠癌患者的组织样本.
- 利用HT-29细胞研究UC中的SIAE分子机制.
- 采用质谱学,西部斑点 (WB),免疫组织化学 (IHC),聚合酶链反应 (PCR) 和免疫光.
主要成果:
- 发现酸乙雌激酶 (SIAE) 在UC组织和TNF-α刺激的HT-29细胞中被上调.
- 刺激TNF-α导致SIAE和NEU1的表达增加了5倍.
- 观察到减少酸乙化和细胞表面酸水平,以及细胞粘附分子 (CDH1,CTNND1,ITGA8) 的表达减少.
结论:
- 在UC中SIAE上调导致酸乙化和细胞表面酸水平降低.
- 这些变化通过降低细胞附着性来破坏粘膜屏障的完整性.
- SIAE介导的酸去乙化是UC病变的关键因素,具有潜在的生物标志物和治疗标.
相关概念视频
Drugs for Treatment of Ulcerative Colitis in IBD
102
Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
102
Inflammatory Bowel Disease I: Ulcerative Colitis
94
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
94
Drugs for Peptic Ulcer Disease: Sucralfate as Mucosal Protective Agents
325
In the intricate landscape of the gastric lumen, excessive acid secretion disrupts the natural defense mechanisms, weakening the mucus-bicarbonate barrier. This vulnerability allows pepsin to infiltrate epithelial cells, digesting mucosal proteins and triggering erosion, leading to ulcer formation.
In this scenario, mucosal protective agents like sucralfate play an essential role. Sucralfate, a complex of sulfated sucrose and aluminum hydroxide, demonstrates its usefulness in acidic conditions,...
In this scenario, mucosal protective agents like sucralfate play an essential role. Sucralfate, a complex of sulfated sucrose and aluminum hydroxide, demonstrates its usefulness in acidic conditions,...
325
Pathophysiology of Peptic Ulcer Disease: Injurious Factors
477
Peptic ulcers are sores on the stomach's inner lining and the upper small intestine, which are the result of disruptions in the mucosal layer that houses parietal cells which produce gastric acid, and chief cells which secrete pepsinogen.
In the antrum region, G cells secrete the gastrin hormone that binds to gastrin-cholecystokinin-B (CCK2) receptors on parietal and enterochromaffin-like (ECL) cells in the fundic glands. Simultaneously, the vagus nerve releases acetylcholine, which binds...
In the antrum region, G cells secrete the gastrin hormone that binds to gastrin-cholecystokinin-B (CCK2) receptors on parietal and enterochromaffin-like (ECL) cells in the fundic glands. Simultaneously, the vagus nerve releases acetylcholine, which binds...
477
Pathophysiology of Peptic Ulcer Disease: Mucosal Defense Factors
305
Peptic ulcer disease, commonly called PUD, represents a multifaceted condition characterized by disruptions in the lining of the gastrointestinal (GI) tract. Central to the protection of the gastrointestinal lining is the mucosal-bicarbonate barrier. This physiological defense mechanism is a formidable shield against the corrosive effects of gastric acid and pepsin secretion in the stomach. Its role is pivotal in maintaining the structural integrity of the stomach's inner lining.
305
Chronic Bowel Disorders: Introduction
310
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
310


