含有ivermectin的固体脂质纳米颗粒对实验性三病肠道阶段的影响
S K Hammad1, M H Almotayam1, A S N Mohamed2
1Department of Medical Parasitology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Journal of helminthology
|April 22, 2025
概括
新型纳米生物技术使用载入固体脂质纳米颗粒 (IVM-SLNs) 的ivermectin有效治疗三病的肠病阶段. 这种方法提高了药物的生物可用性,减少了寄生虫负担,为寄生虫疾病管理提供了一个有希望的替代方案.
科学领域:
- 寄生虫学的寄生虫学
- 纳米医学是一种纳米医学.
- 药物输送系统 药物输送系统
背景情况:
- 三病是一种全球性动物传播疾病,由于药物生物可用性和耐药性差,治疗选择有限.
- 肠道阶段对于疾病进展至关重要,需要有效的治疗策略.
- 纳米生物技术为提高抗寄生虫剂的疗效提供了一个有希望的途径.
研究的目的:
- 调查固体脂质纳米颗粒 (SLN) 的有效性,以改善口服艾弗梅克丁 (IVM) 在治疗三病的肠部阶段的治疗.
- 在小鼠模型中评估ivermectin载入固体脂质纳米粒子 (IVM-SLNs) 的治疗潜力.
- 评估IVM-SLNs单独或与阿尔本达结合对寄生虫负担和宿主反应的影响.
主要方法:
- 35只瑞士白色老鼠被感染了三菌,并被分为七个治疗组.
- 治疗包括负对照,阳性对照,阿尔本达,艾弗梅克丁,SLN,IVM-SLN以及IVM-SLN和阿尔本达的组合.
- 在感染后的第七天通过寄生虫学,生物化学,组织学,组织化学和免疫组织化学分析来评估有效性.
主要成果:
- 同时使用阿尔本达和IVM-SLNs显著降低了成年虫负担,炎症细胞透和亡.
- 在IVM-SLN治疗组中观察到循环氧化酶-2 (COX-2) 表达的显著下降.
- 记录了肝脏和功能指数的改善,表明宿主毒性降低.
结论:
- 单次口服IVM-SLNs剂量显示出对成年Trichinella具有强大的三杀菌作用.
- IVM-SLNs代表了对现有的三菌杀虫剂的有希望的替代或辅助疗法.
- 这种纳米生物技术方法提高了药物的生物可用性和对寄生虫感染的治疗疗效.
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