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长时间坐着和全因死亡率:功能标志物的调解和预测作用
Li Wang1, Xuelei Wu1, Ziyi Guo1
1Changzhou Maternal and Child Health Care Hospital, Changzhou Medical Center of Nanjing Medical University, Changzhou, Jiangsu Province, China.
Renal failure
|April 22, 2025
概括
长时间每天坐着会增加死亡风险,功能标志物,如估计的膜过率 (eGFR) 和尿蛋白肌素比率 (UACR) 起着调解作用. 监测脏健康可以改善久坐不动的人的死亡风险预测.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 久坐不动行为是一个日益严重的公共卫生问题.
- 长时间坐着和死亡率之间的关联需要进一步研究,特别是关于潜在的机制.
- 功能标志物可以提供关于久坐式生活方式的健康风险的见解.
研究的目的:
- 检查每日坐着时间与全因死亡率之间的联系.
- 评估功能标志物对这种关联的调解作用.
- 确定脏标志物对久坐不动的成年人死亡风险的预测值.
主要方法:
- 国家健康和营养检查调查 (NHANES) 数据 (2003-2020) 的横截面分析.
- 评估功能,使用估计的膜过率 (eGFR),尿中白蛋白,肌素比率 (UACR) 和其他生物标志物.
- 统计分析包括生存分析,调解分析和接收器运行特征 (ROC) 曲线分析.
主要成果:
- 增加的坐时间与血液尿素 (BUN),肌素,尿酸,度和UACR的升高相关,并降低了EGFR.
- 每天坐8个小时以上的人,死亡风险高出67%.
- 在eGFR/UACR和死亡率之间发现了非线性关系;eGFR调解了坐着时间与死亡率的20.98%.
- 纳入eGFR或UACR显著改善了死亡率预测 (AUC从0.585增加到0.762/0.656).
结论:
- 长时间的每日坐着时间与所有原因死亡率的增加有显著关联.
- 由eGFR和UACR表示的功能障碍似乎介导了这种风险.
- 功能标志物增强了久坐不动的人群的死亡风险预测.
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