N-cadherin促进三神经元的感觉神经元外生和目标组织内化
Caroline A Halmi1, Carrie E Leonard1, Alec T McIntosh2
1Department of Animal and Avian Sciences, University of Maryland, College Park, MD 20742, USA.
概括
神经干素 (N-干素) 对于三腺体的发育至关重要,它介导着斑点细胞和神经细胞之间的相互作用. 这种分子影响质的大小,神经生长和内,揭示了它在神经元发育中的重要作用.
科学领域:
- 神经科学是一个神经科学.
- 发展生物学 发展生物学
- 细胞生物学 细胞生物学
背景情况:
- 三腺节起源于头骨的斑点和神经细胞.
- 控制三腺形成的分子机制尚未完全理解.
- 神经干素 (N-干素) 参与神经和神经细胞的初始凝聚.
研究的目的:
- 调查N-cadherin在三腺节发育中的作用,特别是轴突外生长和内目标.
- 阐明N-cadherin在这个过程中的细胞和非细胞自主功能.
主要方法:
- 在小的三角位细胞中,N-cadherin被淘汰.
- 在体内分析三腺的大小,神经生长和内 target.
- 在体外评估神经衍生神经元中的神经元复杂性和轴突延伸.
- 在实验室中阻断N-cadherin介导的粘附.
主要成果:
- 在体内,N-cadherin knockdown 降低了三腺的大小,神经生长和内目标.
- 在实验室中观察到神经衍生的神经元的神经元复杂性的降低.
- 在实验室中阻断N-cadherin介导的粘附抑制了 placodal神经元中的轴突延伸.
结论:
- 通过介导神经和神经衍生的神经元之间的相互相互作用,N-cadherin在三角质腺发育中发挥着关键作用.
- 在这种情况下,N-cadherin表现出细胞自主和非细胞自主功能.
- 这些发现强调了N-cadherin对神经元发育,轴突延伸和内目标的重要性.
相关概念视频
Cadherins in Tissue Organization
2.9K
The cadherins are a superfamily of cell adhesion molecules comprising over 180 variants, with specific tissues expressing a particular combination of cadherin types. Cadherins generally exhibit homophilic binding; i.e., cadherins on one cell bind to cadherins of the same or closely related type on another cell. Thus, cells of the same type have a specific affinity to bind to each other and sort themselves into clusters to form tissues.
Cell Sorting During Development
Cell sorting plays an...
Cell Sorting During Development
Cell sorting plays an...
2.9K
Structure of Cadherins
3.2K
The cadherins were one of the first cell adhesion molecules discovered; the term “cadherins” is based on their calcium-dependent adhering properties. The first cadherins discovered on the epithelial, neuronal, and placental cells were named E-cadherin, P-cadherin, and N-cadherin, respectively. These classical cadherins share sequence and structural similarities. Other cadherins, including those involved in cell signaling, are grouped into non-classical cadherins. This...
3.2K
Catenins
2.2K
Catenins are characterized by multiple binding domains and dynamic structures that allow them to function as linker proteins in cell junction complexes. All catenins, except α-catenin, contain a characteristic protein sequence called the armadillo repeat and are therefore also called armadillo proteins.
Catenins in Cell Junctions
Catenins bind to cell adhesion molecules such as cadherins and link them to different cytoskeletal proteins depending on the type of cell junction. At the...
Catenins in Cell Junctions
Catenins bind to cell adhesion molecules such as cadherins and link them to different cytoskeletal proteins depending on the type of cell junction. At the...
2.2K
Role Of Notch Signalling In Intestinal Stem Cell Renewal
2.0K
Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
2.0K
Adherens Junctions
4.6K
Strong contact points between adjacent cells anchor them to each other, forming tissues. Such anchoring junctions are of two types – adherens junctions and desmosomes. Adherens junctions are abundant in tissues such as epithelium and endothelium, forming a continuous zone of adhesion called the adhesion belt. In other tissues, such as heart muscle, they appear as clusters, linking the cells to produce coordinated heart muscle contraction.
Adherens Junctions are Dynamic
Adherens Junctions are Dynamic
4.6K
Notch Signaling Pathway
4.1K
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
4.1K


