相关实验视频
Updated: May 10, 2025

09:47
Isolation, Processing and Analysis of Murine Gingival Cells
Published on: July 2, 2013
18.8K
粘膜湿度,低和局部防御在牙周炎症
Buket Acar1, Mehmet Özcan2, Havanur Toz1
1Faculty of Dentistry, Department of Periodontology, University of Hacettepe, Ankara, Turkey.
Oral diseases
|April 22, 2025
概括
减少粘膜湿度和改变MUC4和TNF-α水平与低和牙周病有关. 粘膜湿可能表明在牙周疾病中局部唾液状况.
科学领域:
- 口腔生物学 口腔生物学
- 牙周病学 牙周病学
- 生物化学 生物化学
背景情况:
- 低水或口腔干燥会影响口腔健康.
- 唾液成分如MUC4和TNF-α在口腔粘膜防御和炎症中起作用.
- 牙周状况受当地口腔环境因素的影响.
研究的目的:
- 研究唾液特性,粘膜状况和牙周健康之间的关系.
- 为了评估hyposalivators与normosalivators中的MUC4和TNF-α水平.
- 探索粘膜湿度 (MW) 和pH值作为唾液状态的指标.
主要方法:
- 根据唾液流量,招募了24名低唾液器和26名正常唾液器.
- 测量了粘膜湿度 (MW) 和pH值,记录了牙周参数,并收集了牙裂液 (GCF).
- 使用ELISA在唾液和GCF中的量化MUC4和TNF-α水平.
主要成果:
- 吸剂的患者表现出较高的牙炎症 (GI) 和探针出血 (BoP),MW和pH值较低.
- 在各组之间观察到MUC4和TNF-α水平的显著差异.
- 在hyposalivators的前部区域,GCF TNF-α升高,而GCF MUC4在normosalivators的部区域更高.
结论:
- 粘膜湿度 (MW) 可以作为牙周病中局部唾液特征的实际指标.
- 了解特定位点的唾液变化对于管理牙周状况至关重要.
- 唾液因子和局部炎症在低度中密切相关.
相关概念视频
Salivary Glands and Saliva
296
The salivary glands, of which there are three pairs known as the parotid, submandibular, and sublingual glands, play a crucial role in maintaining oral health and initiating the digestive process. Positioned near the ears, beneath the masseter muscle, the parotid glands secrete saliva into the oral cavity through the parotid duct of Stensen. Meanwhile, the submandibular glands, located on the floor of the mouth, secrete saliva through channels named submandibular ducts. The sublingual glands,...
296
Pathophysiology of Peptic Ulcer Disease: Mucosal Defense Factors
305
Peptic ulcer disease, commonly called PUD, represents a multifaceted condition characterized by disruptions in the lining of the gastrointestinal (GI) tract. Central to the protection of the gastrointestinal lining is the mucosal-bicarbonate barrier. This physiological defense mechanism is a formidable shield against the corrosive effects of gastric acid and pepsin secretion in the stomach. Its role is pivotal in maintaining the structural integrity of the stomach's inner lining.
305
Peptic Ulcer Disease II: Pathophysiology
151
Peptic Ulcer Disease (PUD) is characterized by the development of ulcers in the stomach or duodenal mucosa. Its pathophysiology is complex, involving a balance between damaging and protective elements.
Damaging agents such as Helicobacter pylori, gastric acid, pepsin, and nonsteroidal anti-inflammatory drugs (NSAIDs) can weaken the mucosal defense, allowing hydrogen ions to infiltrate back and harm epithelial cells.
Damaging agents such as Helicobacter pylori, gastric acid, pepsin, and nonsteroidal anti-inflammatory drugs (NSAIDs) can weaken the mucosal defense, allowing hydrogen ions to infiltrate back and harm epithelial cells.
151
Surface Membrane Barriers
668
The skin and mucous membranes serve as the primary line of defense against pathogens by providing both physical and chemical protection. These barriers are essential in preventing the entry and establishment of microbes, thereby maintaining the integrity of the host.
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
668
Mucosal Barrier of the Stomach
414
The gastric glands contain parietal cells that secrete hydrochloric acid (HCl) for digestion. The cells secrete HCl because it is highly corrosive and essential for breaking down food. To achieve this, they secrete hydrogen and chloride ions into the lumen of the gastric glands, which combine to form HCl.
Within parietal cells, carbonic acid is first formed through the reaction of water and carbon dioxide. The dissociation of carbonic acid releases bicarbonate and hydrogen ions. The bicarbonate...
Within parietal cells, carbonic acid is first formed through the reaction of water and carbon dioxide. The dissociation of carbonic acid releases bicarbonate and hydrogen ions. The bicarbonate...
414
Pathophysiology of Peptic Ulcer Disease: Injurious Factors
477
Peptic ulcers are sores on the stomach's inner lining and the upper small intestine, which are the result of disruptions in the mucosal layer that houses parietal cells which produce gastric acid, and chief cells which secrete pepsinogen.
In the antrum region, G cells secrete the gastrin hormone that binds to gastrin-cholecystokinin-B (CCK2) receptors on parietal and enterochromaffin-like (ECL) cells in the fundic glands. Simultaneously, the vagus nerve releases acetylcholine, which binds...
In the antrum region, G cells secrete the gastrin hormone that binds to gastrin-cholecystokinin-B (CCK2) receptors on parietal and enterochromaffin-like (ECL) cells in the fundic glands. Simultaneously, the vagus nerve releases acetylcholine, which binds...
477

