相关实验视频
Updated: Jul 2, 2026

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A New Murine Model of Endovascular Aortic Aneurysm Repair
Published on: July 7, 2013
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在主动脉或主动脉外围动脉重建中预防感染
Mateus Ab Cristino1, Luis Cu Nakano1,2, Vladimir Vasconcelos1,2
1Department of Surgery, Division of Vascular and Endovascular Surgery, Universidade Federal de São Paulo, São Paulo, Brazil.
The Cochrane database of systematic reviews
|April 22, 2025
概括
预防性抗生素可以预防外科手术部位感染 (SSIs) 在外周动脉疾病 (PAD) 的大动脉重建中. 然而,证据表明,短期和长期使用抗生素或特定类型的抗生素之间没有显著差异.
科学领域:
- 血管外科 血管外科
- 预防传染病 预防传染病
- 基于证据的医学基于证据的医学.
背景情况:
- 周围动脉疾病 (PAD) 和大动脉动脉瘤通常需要进行动脉重建手术.
- 手术部位感染 (SSI) 是这些血管手术的重要并发症.
- 评估SSI的预防措施对于患者的治疗结果和医疗影响至关重要.
研究的目的:
- 评估药理和非药理干预措施在接受大动脉或大动脉外围动脉重建的患者中预防感染的有效性.
- 评估抗微生物疗法,抗毒剂和伤口管理策略.
主要方法:
- 随机对照试验 (RCT) 和准RCT的系统审查和元分析.
- 综合搜索多个数据库,包括Cochrane Vascular,MEDLINE,Embase和临床试验注册表.
- 数据提取和偏差风险评估由两名独立审查员进行,使用GRADE评估证据的确定性.
主要成果:
- 包括21个涉及4952名参与者的RCT,大多数研究具有高或不清楚的偏差风险.
- 预防性抗生素在减少SSI方面显示出潜在的益处 (非常低的确定性证据).
- 短期 (<24小时) 和长期 (>24小时) 抗生素之间,以及不同系统性抗生素类型之间没有发现显著差异.
结论:
- 非常低的确定性证据表明,预防性抗生素可能会减少主动脉/主动脉重建中的SSI.
- 对于特定的抗生素或使用时间长的抗生素,没有证明其优越性.
- 结论应谨慎解释,因为事件有限和研究偏见.
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