使用Passiflora edulis树叶提取物制备和优化纳米颗粒:透和体外释放动力学研究
Acharya Prajakta Namdevrao1, Mohd Sayeed Shaikh2, Pathan Rijawan Rajjak1
1SBSPM's B. Pharmacy College, Modi Learning Centre, Ambajogai, India.
Chemistry & biodiversity
|April 22, 2025
概括
绿色合成的Passiflora edulis-纳米颗粒 (PE-SeNPs) 显示出增强的抗氧化和抗菌特性. 优化的PE-SeNPs表现出更好的溶解性和透性,显示出治疗应用的潜力.
科学领域:
- 纳米技术 纳米技术
- 绿色合成是一种绿色合成.
- 材料科学 材料科学 材料科学
背景情况:
- 帕西弗洛拉埃杜利斯 (PE) 提取物含有生物活性化合物.
- 纳米粒子 (SeNPs) 具有治疗潜力.
- 将PE与SeNPs结合起来,可以创建新的纳米材料.
研究的目的:
- 通过绿色合成,制造Passiflora edulis-纳米粒子 (PE-SeNPs).使用绿色合成.
- 使用Box-Behnken设计优化PE-SeNPs以获得增强的属性.
- 评估PE-SeNPs的可溶性,抗氧化,抗菌,透和释放动力学.
主要方法:
- 绿色合成PE-SeNPs使用PE提取物,烯酸和奇托.
- 盒子-Behnken设计,以优化配方.
- 使用UV-Vis,FTIR和SEM进行表征;评估生物活动和释放动力学.
主要成果:
- 优化的PE-SeNP (4.6毫升PE提取物,29.7毫升Na2SeO3,1.7毫克/毫升奇托) 显示颗粒大小为154-198纳米.
- 与PE提取物 (58%) 相比,PE-SeNPs表现出增强的抗氧化活性 (64%的抑制).
- PE-SeNPs对大肠杆菌和B. subtilis具有显著的抗菌活性,其透系数为0.473厘米/小时,释放动力学为零级.
结论:
- 绿色合成的PE-SeNPs是一种有前途的纳米材料,具有改进的物理化学和生物特性.
- 优化的PE-SeNPs显示了增强的抗氧化和抗菌疗效.
- 该配方表现出有利的透性和受控释放动力学,表明其具有治疗潜力.
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