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Updated: May 10, 2025

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在前列腺癌中,SPOP突变通过CK2/PIAS1/SPOP轴增加了PARP抑制剂的敏感性

Hui Zhang1, Lili Kong2, Jinhui Li1

  • 1Department of Urology, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, China.

JCI insight
|April 22, 2025
PubMed
概括

患有SPOP突变的前列腺癌 (PCa) 细胞表现出基因组不稳定性和对PARP抑制剂 (如olaparib) 的敏感性增加. 干扰CK2/PIAS1/SPOP轴会损害DNA损伤修复 (DDR),从而提高olaparib的疗效.

关键词:
细胞生物学 细胞生物学修复DNA的修复DNA的修复药物治疗是药物治疗.遗传学 是一个遗传学.在瘤学瘤学.前列腺癌是什么意思 前列腺癌是什么意思

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