关于肺癌多基因风险测试的态度:一种混合方法研究
Hoda Badr1, Jinyoung Byun1,2, Melinda C Aldrich3,4,5
1Department of Medicine, Baylor College of Medicine, Houston, TX, United States.
概括
患者对肺癌多基因风险评分 (PRS) 的兴趣受知识,感知到的好处和隐私问题和心理负担等障碍的影响. 需要量身定制的沟通策略来实现公平的采用.
科学领域:
- 基因组学和精准医学精准医学
- 癌症预防和早期检测
- 健康差距 研究 研究 研究 研究
背景情况:
- 多基因风险评分 (PRS) 显示了肺癌早期检测和个性化治疗的潜力.
- 了解患者对基于PRS的基因测试的兴趣至关重要,但目前有限.
- 社会人口结构和个人风险因素可能会影响人们对PRS的态度.
研究的目的:
- 探索与肺癌相关的知识,态度,感知到的好处和障碍.
- 调查患者接受PRS结果的偏好.
- 这项研究以健康信念模型为基础,研究了影响PRS吸收的因素.
主要方法:
- 混合方法研究涉及来自综合癌症中心的141名参与者.
- 对知识,态度,好处和障碍的定量评估.
- 心理影响和结果偏好的定性探索.
主要成果:
- 尽管认识到肺癌的严重程度,参与者对PRS的知识有限.
- 对隐私,心理影响和结果实用性的担忧减少了对PRS测试的兴趣.
- 妇女和非洲裔美国人报告了关于心理影响,耻辱和家庭后果的明显担忧.
结论:
- 对PRS测试的感知好处和障碍受到社会人口统计学和个人风险因素的影响.
- 耻辱感,心理负担和隐私问题极大地影响了人们对PRS的态度.
- 改善风险沟通,确保数据隐私,并提供可操作的指导是提高PRS采用和公平访问的关键.
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