测绘测定致癌物的关键特征,以支持决策
Gabrielle Rigutto1, Cliona M McHale1, Ettayapuram Ramaprasad Azhagiya Singam2
1Division of Environmental Health Sciences, School of Public Health, University of California, 2121 Berkeley Way, Berkeley, CA 94704, United States.
Database : the journal of biological databases and curation
|April 22, 2025
概括
一个新的数据库对致癌物质的10个关键特征 (KCs) 进行了测试和生物标志物目录,有助于用于危险识别的机械数据评估.
科学领域:
- 毒理学和致癌的产生.
- 生物标志物发现发现
- 在化学安全领域的数据科学.
背景情况:
- 致癌物的主要特征 (KCs) 对于危害识别至关重要,但缺乏全面的测试文档.
- 现有的资源部分记录了10个KC的体外/体内测定,生物标志物和终点.
- 国际癌症研究机构 (IARC) 的专著提供了支持性证据,但需要系统的数据链接.
研究的目的:
- 创建一个全面的数据库,将致癌物质的10个KC映射到相关的测试,生物标志物和终点.
- 为了解决部分记录的方法对KC评估的局限性.
- 为了促进机械数据搜索,并支持对致癌物质的危险识别.
主要方法:
- 从以前描述的方法和10个KC的终点/生物标志物中编制的数据.
- 在IARC专著第112-131卷中引用的综合信息.
- 开发了一个公开可访问的基于Web的数据库 (KC-Assay数据库).
主要成果:
- 已经建立了对KC与测试和终点的全面映射.
- 数据库有助于搜索与10个KC相关的测试和终点.
- KC-Assay数据库作为评估每个KC的证据强度的路线图.
结论:
- KC-Assay数据库增强了用于识别致癌物质危险的机械数据搜索.
- 本资源提供了一种系统的方法来评估支持每个KC的证据.
- 数据库是一个活着的文件,公开可用于持续改进和使用.
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