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相关概念视频

Genomics02:02

Genomics

35.3K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
35.3K
Sanger Sequencing01:57

Sanger Sequencing

751.2K
DNA sequencing is a fundamental technique that is routinely used in the biological sciences. This method can be applied to a range of questions at different scales - from the sequencing of a cloned DNA fragment or the study of a mutation in a gene up to whole-genome sequencing. However, despite the widespread use of sequencing today, it was not until 1977 that Fredrick Sanger and his collaborators developed the chain-termination method to decode DNA sequences. It relies on the separation of a...
751.2K
Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

5.6K
Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
5.6K
Genome Annotation and Assembly03:36

Genome Annotation and Assembly

18.7K
The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.
18.7K
Multi-species Conserved Sequences02:51

Multi-species Conserved Sequences

3.8K
Next-generation sequencing technologies have created large genomic databases of a variety of animals and plants. Ever since the human genome project was completed, scientists studied the genome of primates, mammals, and other phylogenetically distant living beings. Such large-scale  studies have provided new insights into the evolutionary relationship between organisms.
Although the genome of each species varies greatly from each other, a few sequences are highly conserved. Such conserved...
3.8K
DNA Microarrays02:34

DNA Microarrays

17.0K
Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...
17.0K

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相关实验视频

Updated: May 10, 2025

A Virtual Machine Platform for Non-Computer Professionals for Using Deep Learning to Classify Biological Sequences of Metagenomic Data
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A Virtual Machine Platform for Non-Computer Professionals for Using Deep Learning to Classify Biological Sequences of Metagenomic Data

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在生物导体社区学习和教学生物数据科学.

Jenny Drnevich1, Frederick J Tan2, Fabricio Almeida-Silva3,4

  • 1Roy J. Carver Biotechnology Center, University of Illinois Urbana-Champaign, Champaign, Illinois, United States of America.

PLoS computational biology
|April 22, 2025
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概括

本指南概述了生物数据科学培训的生物导体项目资源. 它提供了omics数据分析的最佳实践,帮助学习者和教育工作者在这个数据密集型领域.

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Droplet Barcoding-Based Single Cell Transcriptomics of Adult Mammalian Tissues
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Droplet Barcoding-Based Single Cell Transcriptomics of Adult Mammalian Tissues

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Leveraging CyVerse Resources for De Novo Comparative Transcriptomics of Underserved Non-model Organisms
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Leveraging CyVerse Resources for De Novo Comparative Transcriptomics of Underserved Non-model Organisms

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相关实验视频

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A Virtual Machine Platform for Non-Computer Professionals for Using Deep Learning to Classify Biological Sequences of Metagenomic Data
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A Virtual Machine Platform for Non-Computer Professionals for Using Deep Learning to Classify Biological Sequences of Metagenomic Data

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Droplet Barcoding-Based Single Cell Transcriptomics of Adult Mammalian Tissues
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Droplet Barcoding-Based Single Cell Transcriptomics of Adult Mammalian Tissues

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科学领域:

  • 生物信息学是一种生物信息学.
  • 计算生物学 计算生物学
  • 基因组学就是基因组学.

背景情况:

  • 生物研究产生了大量的数据.
  • 生物数据科学方面的有效培训至关重要.
  • 生物导体项目提供了用于OMIC数据分析的开源工具.

研究的目的:

  • 提供生物导体资源的概述.
  • 突出使用生物导体进行omics数据分析的最佳实践.
  • 作为生物数据科学教育的参考.

主要方法:

  • 对生物导体项目文件的审查.
  • 确定用于OMIC数据分析的关键资源.
  • 收集使用生物导体的最佳实践.

主要成果:

  • 生物导体提供了一个全面的软件和资源生态系统.
  • 特定的工具和工作流程有助于进行各种omics数据分析.
  • 最佳实践提高了生物数据科学中的可复制性和效率.

结论:

  • 生物导体是生物数据科学培训的重要资源.
  • 教师和学习者可以利用生物导体进行omics数据分析.
  • 采用生物导体最佳实践改善了研究成果.