性饮食改善了牛皮关节炎的疾病活性和心血管风险:一项概念验证研究
Roberta Ramonda1, Francesca Ometto2, Giovanni Striani1
1Rheumatology Unit, Department of Medicine (DIMED), Padova University Hospital, Padova, Italy.
PloS one
|April 22, 2025
概括
非常低热量类饮食 (VLCKD) 改善了肥胖患者的牛皮关节炎 (PsA) 活动和代谢健康. 较高的基线体重和疾病活性与这种低碳水化合物,低卡路里饮食更大的益处相关.
科学领域:
- 代谢健康 代谢健康
- 类风湿病学 类风湿病学
- 营养科学 营养科学
背景情况:
- 牛皮关节炎 (PsA) 是一种慢性炎症状况,通常与代谢功能障碍和心血管风险有关.
- 过重和肥胖在PsA患者中很常见,可能会加剧疾病活动和并发症.
- 非常低热量类饮食 (VLCKD) 已知可以快速减肥,并具有潜在的抗炎作用.
研究的目的:
- 为了评估9周VLCKD对人体测量,炎症,代谢健康和心血管风险的影响,PSA患者中度超重或I类肥胖.
- 在接受VLCKD的PsA患者中,探索人类参数变化与临床/实验室变量之间的关联.
主要方法:
- 一个概念验证,单臂研究,涉及20名PsA患者 (体质指数[BMI]27-35) 在稳定的低疾病活性.
- 患者遵循了为期9周的VLCKD疗法,每3周进行一次营养评估.
- 分析的重点是BMI的变化,银病关节炎的疾病活动 (DAPSA) 评分,心血管风险 (SCORE2),胰岛素抵抗 (HOMA-IR) 和炎症生物标志物.
主要成果:
- 在VLCKD后,BMI,PsA活性 (DAPSA),心血管风险 (SCORE2) 和胰岛素抵抗 (HOMA-IR) 显著改善.
- 体重指数的降低与DAPSA分数的改善正相关 (rs=0.52,p=0.020).
- 基线体重较高,疾病活性较高的患者体验到更明显的益处.
结论:
- VLCKD是一种有效的干预措施,可以改善超重/肥胖的PsA患者的PsA疾病活性和代谢健康.
- 体重指数较高,疾病活动控制较弱的个体可能特别受益于VLCKD.
- VLCKD显示出作为治疗策略的承诺,用于管理牛皮关节炎的并发症.
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